Protein Phosphatase 4, Regulatory Subunit 2 抗体
(Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2))
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair (By similarity). Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage- dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair (By similarity).
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Latest Publications for our Protein Phosphatase 4, Regulatory Subunit 2 抗体
: "PPP4R2 regulates neuronal cell differentiation and survival, functionally cooperating with SMN." in: European journal of cell biology, Vol. 91, Issue 8, pp. 662-74, (2012) (PubMed).: "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein." in: Molecular & cellular proteomics : MCP, Vol. 8, Issue 1, pp. 157-71, (2009) (PubMed).
: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
Aliases for Protein Phosphatase 4, Regulatory Subunit 2 抗体
protein phosphatase 4 regulatory subunit 2 (PPP4R2) 抗体protein phosphatase 4, regulatory subunit 2 (Ppp4r2) 抗体
protein phosphatase 4, regulatory subunit 2a (ppp4r2a) 抗体
protein phosphatase 4 regulatory subunit 2 S homeolog (ppp4r2.S) 抗体
protein phosphatase 4 regulatory subunit 2 (ppp4r2) 抗体
protein phosphatase 4 regulatory subunit 2 L homeolog (ppp4r2.L) 抗体
protein phosphatase 4, regulatory subunit 2b (ppp4r2b) 抗体
BE691708 抗体
C230060M08Rik 抗体
fe11b04 抗体
PP4R2 抗体
ppp4r2 抗体
ppp4r2-B 抗体
wu:fa17h08 抗体
wu:fc23g05 抗体
wu:fe11b04 抗体
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