(Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008].
Uys, Ramburan, Loos, Kinnear, Korkie, Mouton, Riedemann, Moolman-Smook: "Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C." in: BMC cell biology, Vol. 12, pp. 18, (2011) (PubMed).
Birkeli, Llorente, Torgersen, Keryer, Taskén, Sandvig: "Endosome-to-Golgi transport is regulated by protein kinase A type II alpha." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 1991-7, (2003) (PubMed).
MacDougall, Europe-Finner, Robson: "Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme." in: The Journal of clinical endocrinology and metabolism, Vol. 88, Issue 5, pp. 2194-205, (2003) (PubMed).
Sun, Hug, Bradbury, Frizzell: "Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin." in: The Journal of biological chemistry, Vol. 275, Issue 19, pp. 14360-6, (2000) (PubMed).
Aliases for PRKAR2A 抗体
protein kinase cAMP-dependent type II regulatory subunit alpha (PRKAR2A) 抗体 protein kinase, cAMP-dependent, regulatory, type II, alpha, B (prkar2ab) 抗体 protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A) 抗体 protein kinase, cAMP dependent regulatory, type II alpha (Prkar2a) 抗体 protein kinase cAMP-dependent type 2 regulatory subunit alpha (Prkar2a) 抗体 protein kinase cAMP-dependent type II regulatory subunit alpha (Prkar2a) 抗体 1110061A24Rik 抗体 AI317181 抗体 AI836829 抗体 PKR2 抗体 PRKAR2 抗体 prkar2a 抗体 PRKAR2A 抗体 RII(alpha) 抗体 zgc:85886 抗体