PRDM16 产品
(PR Domain Containing 16 (PRDM16))
Categories
The reciprocal translocation t(1\;3)(p36\;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Featured PRDM16 Categories
PRDM16 抗体
High quality antibodies with extensive validation data.
PRDM16 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PRDM16 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PRDM16 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
- (3)
Cat. No.
ABIN6242535
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7164089
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA, ChIP, FACS
Validations
- (1)
- (1)
Cat. No.
ABIN184809
Quantity
100 μg
Datasheet
Datasheet
Recommended PRDM16 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6974822
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958701
Quantity
96 tests
Datasheet
Datasheet
Recommended PRDM16 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3094786
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3130708
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Saccharomyces cerevisiae
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5710996
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PRDM16 Products
: "PRDM16 Inhibits Cell Proliferation and Migration via Epithelial-to-Mesenchymal Transition by Directly Targeting Pyruvate Carboxylase in Papillary Thyroid Cancer." in: Frontiers in cell and developmental biology, Vol. 9, pp. 723777, (2021) (PubMed).: "Binding Efficacy and Thermogenic Efficiency of Pungent and Nonpungent Analogs of Capsaicin." in: Molecules (Basel, Switzerland), Vol. 23, Issue 12, (2018) (PubMed).
: "Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms." in: British journal of pharmacology, Vol. 173, Issue 15, pp. 2369-89, (2016) (PubMed).
: "Brown adipose tissue regulates glucose homeostasis and insulin sensitivity." in: The Journal of clinical investigation, Vol. 123, Issue 1, pp. 215-23, (2013) (PubMed).
: "Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in normal tissues, including bone marrow, and it is not overexpressed in the t(1;3) cells." in: Oncogene, Vol. 23, Issue 1, pp. 311-6, (2004) (PubMed).
: "Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1." in: Genes, chromosomes & cancer, Vol. 36, Issue 3, pp. 313-6, (2003) (PubMed).
: "A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation." in: Blood, Vol. 102, Issue 9, pp. 3323-32, (2003) (PubMed).
: "A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells." in: Blood, Vol. 96, Issue 9, pp. 3209-14, (2000) (PubMed).
Synonyms and alternative names related to PRDM16
PR/SET domain 16 (PRDM16), PR domain containing 16 (prdm16), PR domain containing 16 (Prdm16), PR/SET domain 16 (Prdm16), 5730557K01Rik, C130091E20, csp1, MEL1, mel1, mKIAA1675, PFM13, PRDM16, wu:fc09g08Protein level used designations for PRDM16
- PR domain containing 16
- fc09g08
- PR domain zinc finger protein 16-like
- MDS1/EVI1-like gene 1
- PR domain zinc finger protein 16
- transcription factor MEL1
- PR domain-containing protein 16
- line 27
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