This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008].
Nuytten, Beke, Van Eynde, Ceulemans, Beullens, Van Hummelen, Fuks, Bollen: "The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing." in: Oncogene, Vol. 27, Issue 10, pp. 1449-60, (2008) (PubMed).
Beullens, Bollen: "The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19855-60, (2002) (PubMed).
Aliases for PPP1R8 抗体
protein phosphatase 1 regulatory subunit 8 (PPP1R8) 抗体 protein phosphatase 1, regulatory subunit 8 (Ppp1r8) 抗体 protein phosphatase 1, regulatory (inhibitor) subunit 8 (Ppp1r8) 抗体 protein phosphatase 1, regulatory subunit 8b (ppp1r8b) 抗体 protein phosphatase 1 regulatory subunit 8 L homeolog (ppp1r8.L) 抗体 protein phosphatase 1 regulatory subunit 8 (Ppp1r8) 抗体 protein phosphatase 1, regulatory subunit 8a (ppp1r8a) 抗体 protein phosphatase 1 regulatory subunit 8 S homeolog (ppp1r8.S) 抗体 6330548N22Rik 抗体 ARD-1 抗体 ard-1 抗体 ARD1 抗体 ard1 抗体 AU044684 抗体 NIPP-1 抗体 nipp-1 抗体 NIPP1 抗体 nipp1 抗体 PPP1R8 抗体 ppp1r8 抗体 PRO2047 抗体 si:ch211-206a7.1 抗体