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this study shows that mitochondrial DNA oxidation induces imbalanced activity of NLRP3 (显示 NLRP3 蛋白)/NLRP6 inflammasomes by activation of caspase-8 (显示 CASP8 蛋白) and BRCC36 in dry eye
In late S/G2 (显示 STRN3 蛋白) phase, the DNA damage-responsive E3 ligase RNF8 (显示 RNF8 蛋白) conjugates K63-linked ubiquitin chains to tankyrase 1 (显示 TNKS 蛋白), while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1 (显示 FAM175B 蛋白)/BRCC36-containing deubiquitinase complex.
findings uncover a pivotal role of BRCC36 DUB in limiting DSB processing and repair and illustrate how cells may physically couple ubiquitin recognition and metabolizing activities for fine tuning of DNA repair processes.
BRCC3 may play a role in B7-H3 (显示 CD276 蛋白)-induced 5-Fu resistance.
BRCC3 inversely correlated with NPC (显示 NPC1 蛋白) overall and relapse-free survival. Its expression was higher in radioresistant NPC (显示 NPC1 蛋白) cells, where BRCC3 knockdown increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest.
BRCC3 likely plays a role as tumor-associated gene in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.
KIAA0157 (显示 FAM175B 蛋白) allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity.
upregulation of BRCC3 expression is associated with glioma.
these data strongly suggest that BRCC3, a deubiquitinating enzyme that is part of the cellular BRCA1 and BRISC complexes, is an important player in angiogenesis and that BRCC3 loss-of-function mutations are associated with moyamoya angiopathy.
NBA1/MERIT40 (显示 BABAM1 蛋白) and BRE (显示 BRE 蛋白) interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes
The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 (显示 NLRP3 蛋白) activity by promoting its deubiquitination.
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
BRCA1/BRCA2-containing complex, subunit 3
, BRCA1-A complex subunit BRCC36
, BRCA1/BRCA2-containing complex subunit 3
, BRCA1/BRCA2-containing complex subunit 36
, BRISC complex subunit BRCC36
, lys-63-specific deubiquitinase BRCC36
, 6.1A protein