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抗Human GIPR 抗体:
抗Mouse (Murine) GIPR 抗体:
抗Rat (Rattus) GIPR 抗体:
Human Polyclonal GIPR Primary Antibody for IHC (p) - ABIN4314158
Snook, Nelson, Dyck, Wright, Holloway: Glucose-dependent insulinotropic polypeptide directly induces glucose transport in rat skeletal muscle. in American journal of physiology. Regulatory, integrative and comparative physiology 2015
Show all 4 Pubmed References
Human Polyclonal GIPR Primary Antibody for IHC (p) - ABIN270972
Prasadan, Koizumi, Tulachan, Shiota, Lath, Paredes, Guo, El-Gohary, Malek, Shah, Gittes: The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas. in Diabetes 2011
Cow (Bovine) Polyclonal GIPR Primary Antibody for IHC (p) - ABIN4314159
Figueiredo, Antunes, Moreira, de Mello, Medeiros, Di Giunta, Lobão-Soares, Linhares, Lin, Mazzuco, Prediger, Walz: Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus. in Peptides 2011
Human Polyclonal GIPR Primary Antibody for FACS, IHC (p) - ABIN391714
Ugleholdt, Pedersen, Bassi, Füchtbauer, Jørgensen, Kissow, Nytofte, Poulsen, Rosenkilde, Seino, Thams, Holst, Holst: Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain. in The Journal of biological chemistry 2011
an association between the GIPR rs2302382 polymorphism and type 2 diabetes mellitus in Egyptian patients.
Data suggest that GIPR (gastric inhibitory polypeptide receptor) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein (显示 HCAR3 抗体) Gs alpha subunit (显示 GNAS 抗体), here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies.
GIPR overexpression does not appear to affect acromegalic patients' clinical features
Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 (显示 GTF3A 抗体) and dynamin (显示 DNM1 抗体) and its subsequent intracellular trafficking. GIP (显示 GIP 抗体) stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes.
The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes.
Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia.
The potential future role of gastric inhibitory peptide (GIP (显示 GIP 抗体)) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade.
Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP (显示 GIP 抗体)-stimulated and unstimulated adipocytes.
GIPR is overexpressed in gastric and duodenal neuroendocrine tumors
GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels.
GIP stimulation induces a switch in GIPR recycling from a rapid endosomal to a slow trans-Golgi network (TGN) pathway. GPCR kinases and b-arrestin2 are required for this switch in recycling.
Microarray analysis revealed that pregnancy-specific glycoprotein 17 (Psg17), a potential CD9 (显示 CD9 抗体)-binding partner, was significantly decreased in GIP (显示 GIP 抗体) receptor-knockout (Gipr-/-) testes.
GIPR signaling in adipose tissue plays a critical role in high fat diet-induced insulin (显示 INS 抗体) resistance and hepatic steatosis in vivo, which may involve IL-6 (显示 IL6 抗体) signaling.
Genetic deletion of both GLP-1 (显示 GCG 抗体) and GIP (显示 GIP 抗体) receptors reveals that they are required to maintain an adequate islet number in adulthood and to maintain normal beta cell responses to glucose.
Results suggest the beneficial effects of glucose-dependent insulinotropic polypeptide (显示 GIP 抗体) on periodontal disease.
Gipr(-/-) offspring of mice exposed to high fat diet(HFD) during pregnancy/lactation became insulin (显示 INS 抗体) resistant and obese and exhibited increased adipose tissue inflammation and decreased peripheral tissue substrate utilization after reintroduction of HFD.
Beta-cell Gipr KO mice exhibit lower levels of meal-stimulated insulin (显示 INS 抗体) secretion, decreased expansion of adipose tissue mass and preservation of insulin (显示 INS 抗体) sensitivity and decreased TCF1 (显示 HNF1A 抗体) expression.
Gipr is expressed in healthy arteries, predominantly in endothelial cells.
These data highlighted the importance of intact GIPR signalling and dietary composition in modulating memory and learning, and hippocampal pathways involved in the maintenance of synaptic plasticity
Functional GIP (显示 GIP 抗体) receptors play a major role in islet compensatory response to high fat feeding in mice.
Data suggest that high levels of blood glucose or AGEs (advanced glycation end products), as seen in hyperglycemia, reduce secretion of insulin (显示 INS 抗体) by pancreatic beta cells via antagonism of GIP (gastric inhibitory polypeptide (显示 GIP 抗体))/GIP (显示 GIP 抗体) receptor signaling.
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
gastric inhibitory polypeptide receptor
, glucagon receptor
, gastric inhibitory polypeptide receptor-like
, glucose-dependent insulinotropic polypeptide receptor
, gastric inhibitory peptide receptor