anti-Dopamine d2 Receptor (DRD2) 抗体产品概述

Human Dopamine Receptor D2 (DRD2) interaction partners

1. we failed to identify any associations of DRD2 rs1800497, DRD4 120 bp Ins, or DRD4 exon III polymorphisms with aggression in African populations of Hadza and Datoga

2. The current meta-analysis suggests that ANKK1 Taq1A and DRD2 C957T polymorphisms have limited if any effect on the performance on executive function tasks in healthy adults.

3. Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele. These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.

4. Fourteen healthy adult subjects underwent PET with [(18)F]fallypride, a radiotracer with strong affinity for DRD2, and fMRI (on a separate day) while performing a reward valuation task. [(18)F]fallypride binding potential, reflecting DRD2 availability, in the midbrain correlated positively with neural activity associated with expected value, specifically in the left ventral striatum/caudate.

5. Meta-analysis found that the minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking and higher plasma cotinine levels. This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent response during reward anticipation and with higher DRD2 gene expression in the striatum, but not with TTC12 or ANKK gene expression.

6. Perinatal hypoxia could influence neural development through different biological pathways depending on D2 receptor genotype.

7. Expression analysis indicated that miR-4301 was inversely correlated with DRD2 expression in breast cancer specimens. qRT-PCR showed that miR-4301 negatively regulated DRD2 expression. Downregulation of DRD2 expression in MDA-MB-231, MCF-7, and SKBR3 cells suppressed cell proliferation and promoted apoptosis.

8. Association studies of DRD2 receptor genes and schizophrenia have yielded varying results across different Indian populations.

9. In the presented study, one of selected polymorphisms of DRD2 gene, revealed to be correlated with substance use disorder (at the limit of statistical significance), which could suggest its impact on dependence endophenotype. The presented research was a pilot study, so it requires replication on a larger group of patients to verify and confirm obtained outcomes.

10. The rs6277 polymorphism in the DRD2 gene is an important variant that is thought to regulate D2 receptor availability in the striatum.

11. results suggest a genetic background associated with sugar consumption among West Mexicans.

12. Genetic variations in SLC6A3 and DRD2 may play an important role in pain expression among the elderly prior to orthopedic surgery

13. The findings of this study suggest that genetic subgrouping, in particular for DRD2, may be used to identify Parkinson's disease patient subgroups that are more dopamine responsive for gait function

14. Study results supported the hypothesis that DRD2 affected risperidone treatment. DRD1 had no significant effect on the response to risperidone, whereas DRD3 might be associated with an improvement in negative symptoms. [systematic review and meta-analysis]

15. The carriers of DRD2 risk haplotypes is at increased risk of dyskinesia.

16. Study found a 35.8 kilobases haplotype spanning ANKK1 and DRD2 is associated with heroin dependence in Han Chinese males. Study highlights the importance of considering haplotypes spanning adjacent genes and the cooperation and interaction of proximal variants or genes in genetic association studies.

17. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, the results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission.

18. The more methamphetamine users chose to view methamphetamine images, the lower was their DRD2-type binding potential in the lateral orbitofrontal cortex, an important region in value-based choice.

19. the DRD2 Taq1A A1 allele magnifies the risk of Alzheimer's in aging African-Americans.

20. Results dhow that the presence of T allele (C/T, T/T) in c.957C > T SNP was associated with difficulty in impulse control, self-control of emotions, and conduct adjustment, which can contribute to improving the identification of mental and behavioral phenotypes associated with gene expression.

Cow (Bovine) Dopamine Receptor D2 (DRD2) interaction partners

1. Studied a novel Dopamine Receptor 2 (DRD2) G/A SNP for resistance to fescue toxicosis.

Mouse (Murine) Dopamine Receptor D2 (DRD2) interaction partners

1. results suggest that the stimulation of D2R increases leptin production and may have a tissue-specific pro-inflammatory effect in adipocytes

2. The absence of the D2 dopamine receptor (D2R) increased impulsive behavior in mice, whereas restoration of D2R expression specifically in the central amygdala of D2R knockout mice normalized their enhanced impulsivity.

3. Drd2 signaling in the striatum alters the relationship between effort expenditure and extracellular dopamine.

4. Drd2 and Htr3a genes may play the key role in the synchronization of other genes of neurotransmitter systems in the ventral tegmental area of depressive male mice.

5. The reduction in goal-directed behavior is associated with dysfunction of D2R signaling via increased peripheral PYY.

6. The finding confirm the role of the dopamine D2 autoreceptors in reversal learning and suggest a broader involvement in behavioral inhibition mechanisms.

7. Results present evidence for the role of D2 dopamine receptors in structural alterations induced by the administration of the typical antipsychotic haloperidol and that chronic administration of clozapine has a limited influence on brain structure.

8. Impaired recruitment of dopamine neurons occurred during working memory in mice with striatal D2 receptor overexpression.

9. Findings show that loss-of-function of dopamine receptor type 2-expressing striatal medium spiny neurons (D2-MSNs) within ventrolateral striatum (VLS) is sufficient to reduce goal-directed behaviours.

10. Dopamine 2 receptor upregulation is associated with obesity.

11. D1/D2 medium spiny neurons in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson's disease.

12. The present study evaluates the behavioral effects of pharmacological manipulation and genetic blockade of A2A R and D2 R within the frame of such a predominant striatal heteromeric population.

13. DRD2 in primary mesencephalic neurons had a significant regulative effect on the adipogenesis genes.

14. Dopamine D2 receptor deletion from parvalbumin interneurons in mouse causes an impaired inhibitory activity in the ventral hippocampus and a dysregulated dopaminergic system resulting in schizophrenia-like phenotypes.

15. boosting dopamine signaling in the striatum by acute cocaine administration reveals that absence of D2L, but not of D2S, strongly impairs the motor and cellular response to the drug, in a manner similar to the ablation of both isoforms. These results suggest that when the dopamine system is challenged, D2L signaling is required for the control of striatal circuits regulating motor activity.

16. These findings suggest the importance of Paraventricular Thalamus inhibition by D2Rs in modulating the sensitivity to cocaine, a finding that may have novel implications for human drug use.

17. This study explored the spatial distribution of D2 medium-sized spiny neurons across the rostral-caudal axis of the striatum using D2-eGFP double transgenic mice.

18. Pre- and postsynaptic colocalization of kappa opioid receptor and D2R supports a role for kappa opioid receptor potentiating both the D2R inhibitory autoreceptor function and the inhibitory action of D2R on efferent medium spiny neurons. Kappa opioid receptor co-activation accelerates D2R sensitization by contributing to decrease dopamine release in the nucleus accumbens.

19. Study shows that social isolation to a series of schizophrenia-related deficits and that potential interactions among histidine triad nucleotide binding protein 1, NMDA receptor 1, and dopamine receptor 2 may underlie the behavioral deficits induced by social isolation.

20. These results are in support of intrastriatal connections of D2R(+)-MSNs (iMSNs) with dMSNs and indicate that D2R signaling in MSNs is critical for the function of intrastriatal circuits.

Rhesus Monkey Dopamine Receptor D2 (DRD2) interaction partners

1. Study shows that blocking dopamine D1Rs or stimulating dopamine D2Rs increased low-frequency theta and alpha oscillations known to be involved in learning and memory. In contrast, only D1R inhibition enhanced high-frequency beta oscillations, whereas only D2R stimulation increased gamma oscillations linked to top-down and bottom-up attentional processing.

2. findings highlight complementary modulatory contributions of dopamine d1 & d2 receptors to the neuronal circuitry mediating executive functioning and goal-directed behavior.

3. Extrastriatal D2, D3, and D4 receptor activation in external pallidal segments also influences direct pathway elements in the basal ganglia under normal and parkinsonian conditions.

4. Mapped associations occur between changes in D2 and D3 dopamine receptor occupancy and brain hemodynamics

5. These data provide evidence for a predisposition to self-administer cocaine based on dopamine D2 receptor availability, and demonstrate that the brain dopamine system responds rapidly following cocaine exposure.

Horse (Equine) Dopamine Receptor D2 (DRD2) interaction partners

1. The amount of dopamine d1 receptor, dopamine D2 receptor, and follicle stimulating hormone receptor mRNA were quantified in ovarian tissues in anestrous and mares expressing estrus during the breeding season are reported.

Pig (Porcine) Dopamine Receptor D2 (DRD2) interaction partners

1. The pig DRD2 gene was cloned, investigated its distribution in tissues and polymorphisms were identified.

2. The increase in NOS protein seen in both the endothelium and vascular smooth muscle in response to cerebral vasospasm is enhanced by dopamine in a D(2)R-dependent mechanism.

Fruit Fly (Drosophila melanogaster) Dopamine Receptor D2 (DRD2) interaction partners

1. Damb receptor uniquely activates Gq to mobilize Ca(2+) signaling with greater efficiency and dopamine sensitivity

2. Findings suggest a role for dopamine D1-like receptor Dop1R2 in the repression of genes that coordinate metamorphosis.

3. Results suggest that the activation state of DAMB protein contributes to oxidative stress susceptibility in Drosophila and lead to a proposed model for paraquat neurotoxicity.

4. DD2R gene is expressed in the fat body, and its expression is higher in young females than in sexually mature females. The DD2R gene expression was not detected in ovarian follicular cells.

Guinea Pig Dopamine Receptor D2 (DRD2) interaction partners

1. Dopamine D2 receptor play role in memory consolidation.