Dopamine d2 Receptor 抗体 (Extracellular, N-Term)
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Quick Overview for Dopamine d2 Receptor 抗体 (Extracellular, N-Term) (ABIN7043107)
抗原
See all Dopamine d2 Receptor (DRD2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-26, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to D2 Dopamine Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 15,16 amino acid residues identical
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产品特性
- Anti-D2 Dopamine Receptor (extracellular) Antibody (ABIN7043107, ABIN7044229 and ABIN7044230) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize DRD2 from rat, human, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DDLERQNWSRPFNGSE, corresponding to amino acid residues 11-26 of rat DRD2
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亚型
- IgG
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anti-Dopamine Receptor D2 (DRD2) (AA 194-421) antibody
DRD2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D2 (DRD2) (AA 201-300) antibodyDRD2 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D2 (DRD2) (AA 1-110) antibodyDRD2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B11 unconjugated
anti-Dopamine Receptor D2 (DRD2) (Cytoplasmic Domain) antibodyDRD2 适用: 人, 犬, Bat, Cow, 马, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D2 (DRD2) (AA 307-336), (C-Term) antibodyDRD2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D2 (DRD2) (AA 301-400) antibodyDRD2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D2 (DRD2) (AA 201-300) antibody (AbBy Fluor® 488)DRD2 适用: 人, 大鼠, 小鼠 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 488
anti-Dopamine Receptor D2 (DRD2) antibodyDRD2 适用: 犬 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D2 (DRD2) (AA 214-373) antibodyDRD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D2 (DRD2) (AA 11-26), (Extracellular), (N-Term) antibody (FITC)DRD2 适用: 大鼠 FACS, LCI 宿主: 兔 Polyclonal FITC
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应用备注
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WB: 1:200
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IP|IFC
Negative Control: (ABIN7235239)
Blocking Peptide: (ABIN7235239)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Dopamine d2 Receptor (DRD2) (Dopamine Receptor D2 (DRD2))
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别名
- DRD2
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背景
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Synonyms: DRD2, D(2) dopamine receptor
Description: The D2 dopamine receptor (DRD2) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and endocrine regulation. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and schizophrenia.1All five dopamine receptors belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).1The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.1D2 receptor expression in the brain is largely confined to the striatum, prefrontal cortex and hypothalamus.1Dysregulation of D2 receptor function has been implicated in several disorders including schizophrenia, bipolar disorder, Parkinson's disease, and restless legs syndrome. Consistent with this, treatments that either block or activate the D2 receptor have been developed to treat these diseases.2
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基因ID
- 24318
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NCBI登录号
- NM_000795
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UniProt
- P61169
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途径
- Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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