The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010].
Fløyel, Brorsson, Nielsen, Miani, Bang-Berthelsen, Friedrichsen, Overgaard, Berchtold, Wiberg, Poulsen, Hansen, Rosinger, Boehm, Ram, Nguyen, Mehta, Morahan, Concannon, Bergholdt, Nielsen, Reinheckel et al.: "CTSH regulates ?-cell function and disease progression in newly diagnosed type 1 diabetes patients. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 28, pp. 10305-10, (2014) (PubMed).
Faiz, Tjin, Harkness, Weckmann, Bao, Black, Oliver, Burgess: "The expression and activity of cathepsins D, H and K in asthmatic airways." in: PLoS ONE, Vol. 8, Issue 3, pp. e57245, (2013) (PubMed).
Waghray, Keppler, Sloane, Schuger, Chen: "Analysis of a truncated form of cathepsin H in human prostate tumor cells." in: The Journal of biological chemistry, Vol. 277, Issue 13, pp. 11533-8, (2002) (PubMed).
del Re, Shuja, Cai, Murnane: "Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas." in: British journal of cancer, Vol. 82, Issue 7, pp. 1317-26, (2000) (PubMed).
Aliases for Cathepsin H 抗体
cathepsin H (ctsh) 抗体 cathepsin H (CTSH) 抗体 cathepsin H L homeolog (ctsh.L) 抗体 cathepsin H (Ctsh) 抗体 ACC-4 抗体 ACC-5 抗体 AL022844 抗体 CPSB 抗体 CTSH 抗体 fc44c02 抗体 minichain 抗体 wu:fc44c02 抗体 zgc:85774 抗体