This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Perotti, De Vecchi, Testi, Lualdi, Modena, Mondini, Ravagnani, Collini, Di Renzo, Spreafico, Terenziani, Sozzi, Fossati-Bellani, Radice: "Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14." in: Human mutation, Vol. 24, Issue 5, pp. 400-7, (2004) (PubMed).
Aliases for POU6F2 抗体
POU class 6 homeobox 2 (POU6F2) 抗体 POU domain, class 6, transcription factor 2 (Pou6f2) 抗体 POU domain, class 6, transcription factor 2 (LOC483249) 抗体 POU class 6 homeobox 2 (Pou6f2) 抗体 POU class 6 homeobox 2 (pou6f2) 抗体 D130006K24Rik 抗体 RPF-1 抗体 si:ch211-124o16.3 抗体 WT5 抗体 WTSL 抗体