Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.
Galiègue-Zouitina, Quief, Hildebrand, Denis, Lecocq, Collyn-dHooghe, Bastard, Yuille, Dyer, Kerckaert: "Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation." in: Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie, Vol. 318, Issue 11, pp. 1125-31, (1996) (PubMed).
Luo, Roeder: "Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B." in: Molecular and cellular biology, Vol. 15, Issue 8, pp. 4115-24, (1995) (PubMed).
Strubin, Newell, Matthias: "OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins." in: Cell, Vol. 80, Issue 3, pp. 497-506, (1995) (PubMed).
Aliases for POU2AF1 抗体
POU class 2 associating factor 1 (POU2AF1) 抗体 POU class 2 associating factor 1 (Pou2af1) 抗体 POU domain, class 2, associating factor 1 (Pou2af1) 抗体 BOB-1 抗体 Bob-1 抗体 BOB.1 抗体 BOB1 抗体 Bob1 抗体 OBF-1 抗体 OBF.1 抗体 OBF1 抗体 OCA-B 抗体 OCAB 抗体