(Polymerase (RNA) III (DNA Directed) Polypeptide H (22.9kD) (POLR3H))
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa- B through the RIG-I pathway (By similarity).
Collins, Wright, Edwards, Davis, Grinham, Cole, Goward, Aguado, Mallya, Mokrab, Huckle, Beare, Dunham: "A genome annotation-driven approach to cloning the human ORFeome." in: Genome biology, Vol. 5, Issue 10, pp. R84, (2004) (PubMed).
Aliases for POLR3H 抗体
polymerase (RNA) III (DNA directed) polypeptide H (Polr3h) 抗体 RNA polymerase III subunit H (Polr3h) 抗体 RNA polymerase III subunit H (POLR3H) 抗体 5031409G22Rik 抗体 RPC8 抗体 RPC22.9 抗体