Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation (By similarity).
PTN
宿主: 人
宿主: HEK-293 Cells
Recombinant
The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
AM, ADA, IA, ScA
Wang, LeBlanc, Chen, Chen, Ji, Brewer, Tian, Spring, Webster, Li: "Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease." in: Angiogenesis, Vol. 20, Issue 4, pp. 479-492, (2018) (PubMed).