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Pleiotrophin 产品

(Pleiotrophin (PTN))
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation (By similarity).

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Featured Pleiotrophin Categories

Pleiotrophin 抗体

High quality antibodies with extensive validation data.

Pleiotrophin ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Pleiotrophin 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Pleiotrophin 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (8)
  • (5)
Cat. No. ABIN562528
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7433426
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (2)
Cat. No. ABIN740370
Quantity 100 μL
Datasheet Datasheet

Recommended Pleiotrophin ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (4)
Cat. No. ABIN6574270
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6958661
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962237
Quantity 96 tests
Datasheet Datasheet

Recommended Pleiotrophin 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275498
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7320789
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316796
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Pleiotrophin Products

He, Boulant, Stanifer, Guo, Nießen, Chen, Felix, Bergmann, Strobel, Schimmack: "The link between menin and pleiotrophin in the tumor biology of pancreatic neuroendocrine neoplasms." in: Cancer science, Vol. 113, Issue 5, pp. 1575-1586, (2022) (PubMed).

Wu, Xu, Bao, Gao, Chen, Zhang, Chen, Hong, Xue, Jiang, Liu, Huang, Sun, Fu, Li, Cui: "Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotrophin." in: The Journal of biological chemistry, Vol. 298, Issue 10, pp. 102443, (2022) (PubMed).

Hauser, Kaminski, Syring, Holdenrieder, Dieckmann, Muller, Ellinger: "Evaluation of Serum Biomarkers (FGF-2, HGF, MIF and PTN) in Patients With Testicular Germ Cell Cancer." in: In vivo (Athens, Greece), Vol. 33, Issue 6, pp. 1935-1940, (2020) (PubMed).

Nikolakopoulou, Montagne, Kisler, Dai, Wang, Huuskonen, Sagare, Lazic, Sweeney, Kong, Wang, Owens, Lawson, Xie, Zhao, Zlokovic: "Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss." in: Nature neuroscience, Vol. 22, Issue 7, pp. 1089-1098, (2019) (PubMed).

Wang, LeBlanc, Chen, Chen, Ji, Brewer, Tian, Spring, Webster, Li: "Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease." in: Angiogenesis, Vol. 20, Issue 4, pp. 479-492, (2018) (PubMed).

Zhang, Liu, Liu, Zhou, Song, Cao, An: "miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression." in: PLoS ONE, Vol. 12, Issue 7, pp. e0179783, (2017) (PubMed).

Terkawi, Nishimura, Furuoka, Nishikawa: "Depletion of Phagocytic Cells during Nonlethal Plasmodium yoelii Infection Causes Severe Malaria Characterized by Acute Renal Failure in Mice." in: Infection and immunity, Vol. 84, Issue 3, pp. 845-55, (2016) (PubMed).

Zhu, Bai, Yu, Pan, Jin, Song, Xu, Yao, Huang, Tao, Li, Zhao: "The effects of pleiotrophin in proliferative diabetic retinopathy." in: PLoS ONE, Vol. 10, Issue 1, pp. e0115523, (2015) (PubMed).

Koutsioumpa, Polytarchou, Courty, Zhang, Kieffer, Mikelis, Skandalis, Hellman, Iliopoulos, Papadimitriou: "Interplay between ?v?3 integrin and nucleolin regulates human endothelial and glioma cell migration." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 343-54, (2013) (PubMed).

Kaspiris, Mikelis, Heroult, Khaldi, Grivas, Kouvaras, Dangas, Vasiliadis, Lioté, Courty, Papadimitriou: "Expression of the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in the serum, cartilage and subchondral bone of patients with osteoarthritis." in: Joint, bone, spine : revue du rhumatisme, Vol. 80, Issue 4, pp. 407-13, (2013) (PubMed).

Synonyms and alternative names related to Pleiotrophin

pleiotrophin (ptn), pleiotrophin (PTN), pleiotrophin L homeolog (ptn.L), pleiotrophin (Ptn), harp, HARP, HB-GAM, HBBM, HBBN, HBGF-8, hbgf8, HBGF8, hbnf, HBNF, Hbnf, negf1, NEGF1, OSF, OSF-1, Osf-1, Osf1, ptn, PTN, PTN-A, X-PTF, zgc:111787, zHBNF

Protein level used designations for Pleiotrophin

  • heparin-binding neurite-promoting factor
  • pleiotrophin
  • pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
  • Pleiotrophin
  • HB-GAM
  • HBBM
  • HBGF-8
  • HBNF-1
  • OSF-1
  • heparin affin regulatory protein
  • heparin binding growth factor 8
  • heparin-binding brain mitogen
  • heparin-binding growth factor 8
  • heparin-binding growth-associated molecule
  • heparin-binding neurite outgrowth-promoting factor 1
  • neurite growth-promoting factor 1
  • osteoblast-specific factor 1
  • PTF-beta-1
  • X-PTF-beta1
  • pleiotrophic factor-beta-1
  • pleiotrophin-A
  • heparin-binding neutrophic factor
  • p18
  • heparin affin regulatory peptide
  • heparin-binding neurite promoting factor
  • heparin-binding neurotorphic factor
  • osteoblastic cell factor
  • Pleiotrophin (Heparine binding factor, Hbnf, in the mouse)
  • heparin binding factor
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