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抗Rat (Rattus) PDPK1 抗体:
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抗Mouse (Murine) PDPK1 抗体:
Human Polyclonal PDPK1 Primary Antibody for IHC - ABIN966816
Scheid, Parsons, Woodgett: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. in Molecular and cellular biology 2005
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Human PDPK1 Primary Antibody for IHC - ABIN966815
Chen, Nystrom, Dong, Li, Song, Liu, Quon: Insulin stimulates increased catalytic activity of phosphoinositide-dependent kinase-1 by a phosphorylation-dependent mechanism. in Biochemistry 2001
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Human Polyclonal PDPK1 Primary Antibody for WB - ABIN250778
Ho, Coomber: Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. in Experimental cell research 2015
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Human Polyclonal PDPK1 Primary Antibody for ICC, IF - ABIN250776
Tsoi, Li, Chen, Lau, Tsui, Chan: The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling. in The Biochemical journal 2014
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Human Monoclonal PDPK1 Primary Antibody for ICC, FACS - ABIN969347
Seong, Jung, Kim, Ha: 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins. in The Journal of biological chemistry 2007
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Human Polyclonal PDPK1 Primary Antibody for IF, IHC - ABIN361882
Sato, Fujita, Tsuruo: Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. in The Journal of biological chemistry 2002
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Human Monoclonal PDPK1 Primary Antibody for ICS - ABIN1177138
Komander, Kular, Deak, Alessi, van Aalten: Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding. in The Journal of biological chemistry 2005
Human Polyclonal PDPK1 Primary Antibody for IF (p), IHC (p) - ABIN744668
Lin, Lin, Kang, Liu, Wang, Zheng, Yu, Lin: Similar PDK1-AKT-mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy. in Epilepsy research 2015
Human Polyclonal PDPK1 Primary Antibody for IF, IHC - ABIN362492
Lim, Kikani, Wick, Dong: Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function. in Proceedings of the National Academy of Sciences of the United States of America 2003
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miR (显示 MYLIP 抗体)-375 directly targeted PDK1 (显示 PDK1 抗体) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.
the combination of BX-912 and ABT-263, a BH3 mimetic, resulted in the enhancement of the induction of apoptosis. In conclusion, our results suggest that PDPK1 is a potential novel therapeutic target in Mantle cell lymphoma (MCL (显示 FH 抗体)) and indicate that clinical development of PDPK1-targeted therapy for MCL (显示 FH 抗体) is desirable.
Our experimental results suggested that PDK1 (显示 PDK1 抗体) may promote chondrocyte apoptosis in osteoarthritis via p38 MAPK (显示 MAPK14 抗体) signaling pathway
our results offer significant insight into how PIK3CA (显示 PIK3CA 抗体) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K (显示 PIK3CA 抗体)/PDK1 (显示 PDK1 抗体) and TGFb (显示 TGFB1 抗体) signaling in advanced HNSCC patients with PIK3CA (显示 PIK3CA 抗体) amplification
Ribociclib, in combination with GSK2334470 or the PI3Kalpha (显示 PIK3CA 抗体) inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. Taken together, our results highlight a role for the PI3K (显示 PIK3CA 抗体)-PDK1 (显示 PDK1 抗体) signaling pathway in mediating acquired resistance to CDK4/6 (显示 CDK4 抗体) inhibitors.
Decreased PDK1 (显示 PDK1 抗体) protein expression in A2058 cells.
Together these results indicate a strong potential regulatory role for PDK1 (显示 PDK1 抗体) in OC stimulatory pathways (Akt (显示 AKT1 抗体), ERK (显示 EPHB2 抗体)) and autophagy induction (via mTORC1), which may contribute to the OC phenotype in Paget's disease of bone.
It targeted the 3-phosphoinositide-dependent protein kinase 1 gene that appeared to be a potent regulator of AKT (显示 AKT1 抗体).
High (显示 PDK1 抗体)ly expressed PDK1 could promote cell invasion and secretion of IL-1beta and IL-6 in human rheumatoid arthritis s (显示 PDK1 抗体)ynovial (显示 PDK1 抗体)MH7A c (显示 RPS6KA3 抗体)ells. Inhib (显示 RPS6KA3 抗体)ition of RSK2 reduced the PDK (显示 ASF1A 抗体)1-induced cell invasion and cytokines secretion (显示 PDK1 抗体) in M (显示 RPS6KA3 抗体)H7A cells. In response to TNF-alpha, PDK1 could phosphorylate RSK2 and activated RSK2, then promoting the activation of NF-kappaB.
In cancer cells resistant to PI3Kalpha (显示 PIK3CA 抗体) inhibition, PDK1 (显示 PDK1 抗体) blockade restores sensitivity to these therapies. SGK1 (显示 SGK1 抗体), which is activated by PDK1 (显示 PDK1 抗体), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (显示 TSC2 抗体).
Results suggest that Ser (显示 SIGLEC1 抗体)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (显示 PDK1 抗体)-PKCtheta (显示 PRKCQ 抗体);-mediated T cell activation.
our results offer significant insight into how PIK3CA (显示 PIK3CA 抗体) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 and TGFb (显示 TGFB1 抗体) signaling in advanced HNSCC patients with PIK3CA (显示 PIK3CA 抗体) amplification
PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of asymmetric cell division and the Notch (显示 NOTCH1 抗体)-dependent differentiation program.
Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.
PDK1 was highly expressed in synovia of collagen-induced-arthritis mice compared to control. The expressions of PDK1, p-PDK1, RSK2 (显示 RPS6KA3 抗体) and p-RSK2 (显示 RPS6KA3 抗体) were all up-regulated in CIA (显示 NCOA5 抗体) compared with normal. This indicated that PDK1/RSK2 (显示 RPS6KA3 抗体) may participate in inflammatory progress of RA.
PDK1 is required for Ca(2 (显示 CA2 抗体)+)-dependent platelet activation on stimulation of collagen receptor (显示 ITGA2 抗体) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.
In conclusion, we have identified that ARL15 acts as an insulin (显示 INS 抗体)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (显示 IRS1 抗体)/PDPK1/AKT (显示 AKT1 抗体) insulin (显示 INS 抗体) pathway by interacting with its GAP ASAP2 (显示 ASAP2 抗体) and activating PDPK1. This research may provide new insights into GTPase (显示 RACGAP1 抗体)-mediated insulin (显示 INS 抗体) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (显示 INS 抗体) sensitizati
Only when suboptimal doses of Akt (显示 AKT1 抗体)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (显示 NOTCH1 抗体) inhibition was seen. We conclude that the Akt (显示 AKT1 抗体) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (显示 AKT1 抗体) signaling.
Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (显示 NFKB1 抗体).
PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.
The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.
at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (显示 PIK3C3 抗体) (PI3K)
Piriformospora indica-stimulated growth response is mediated by a pathway consisting of the PLD-PDK1-OXI1 cascade.
PDK1 (显示 PDK1 抗体) undergoes autophosphorylation at several sites; mutation of Ser (显示 SIGLEC1 抗体)-276 to Ala resulted in enzyme with no detectable autophosphorylation; other sites important for autophosphorylation &/or activity were Asp (显示 ASIP 抗体)-167, Thr (显示 TRH 抗体)-176, & Thr (显示 TRH 抗体)-211
PDK1 (显示 PDK1 抗体) is a potent enhancer of PID (显示 MTA2 抗体) activity.
specific lipid signaling pathways converge on PTI1-2 via the PDK1-OXI1 axis
Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.
3-phosphoinositide-dependent protein kinase 1
, 3-phosphoinositide dependent protein kinase-1
, pkB kinase
, protein kinase B kinase
, PkB kinase like gene 1
, Pkb kinase