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Human Polyclonal PDPK1 Primary Antibody for IHC - ABIN966816
Scheid, Parsons, Woodgett: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. in Molecular and cellular biology 2005
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Human PDPK1 Primary Antibody for IHC - ABIN966815
Chen, Nystrom, Dong, Li, Song, Liu, Quon: Insulin stimulates increased catalytic activity of phosphoinositide-dependent kinase-1 by a phosphorylation-dependent mechanism. in Biochemistry 2001
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Human Monoclonal PDPK1 Primary Antibody for ICC, FACS - ABIN969347
Seong, Jung, Kim, Ha: 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins. in The Journal of biological chemistry 2007
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Human Polyclonal PDPK1 Primary Antibody for WB - ABIN250778
Ho, Coomber: Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. in Experimental cell research 2015
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Human Polyclonal PDPK1 Primary Antibody for ICC, IF - ABIN250776
Tsoi, Li, Chen, Lau, Tsui, Chan: The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling. in The Biochemical journal 2014
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Human Polyclonal PDPK1 Primary Antibody for ELISA, WB - ABIN269845
Sarbassov, Guertin, Ali, Sabatini: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. in Science (New York, N.Y.) 2005
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Human Polyclonal PDPK1 Primary Antibody for IF, IHC - ABIN361882
Sato, Fujita, Tsuruo: Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. in The Journal of biological chemistry 2002
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Human Monoclonal PDPK1 Primary Antibody for ICS - ABIN1177136
Komander, Kular, Deak, Alessi, van Aalten: Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding. in The Journal of biological chemistry 2005
Human Monoclonal PDPK1 Primary Antibody for ICS - ABIN1177137
Wick, Ramos, Chen, Quon, Dong, Liu: Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop. in The Journal of biological chemistry 2003
miR (显示 MYLIP 抗体)-375 directly targeted PDK1 (显示 PDK1 抗体) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.
our results offer significant insight into how PIK3CA (显示 PIK3CA 抗体) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K (显示 PIK3CA 抗体)/PDK1 (显示 PDK1 抗体) and TGFb (显示 TGFB1 抗体) signaling in advanced HNSCC patients with PIK3CA (显示 PIK3CA 抗体) amplification
Ribociclib, in combination with GSK2334470 or the PI3Kalpha (显示 PIK3CA 抗体) inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. Taken together, our results highlight a role for the PI3K (显示 PIK3CA 抗体)-PDK1 (显示 PDK1 抗体) signaling pathway in mediating acquired resistance to CDK4/6 (显示 CDK4 抗体) inhibitors.
Decreased PDK1 (显示 PDK1 抗体) protein expression in A2058 cells.
Together these results indicate a strong potential regulatory role for PDK1 (显示 PDK1 抗体) in OC stimulatory pathways (Akt (显示 AKT1 抗体), ERK (显示 EPHB2 抗体)) and autophagy induction (via mTORC1), which may contribute to the OC phenotype in Paget's disease of bone.
It targeted the 3-phosphoinositide-dependent protein kinase 1 gene that appeared to be a potent regulator of AKT (显示 AKT1 抗体).
High (显示 PDK1 抗体)ly expressed PDK1 could promote cell invasion and secretion of IL-1beta and IL-6 in human rheumatoid arthritis s (显示 PDK1 抗体)ynovial (显示 PDK1 抗体)MH7A c (显示 RPS6KA3 抗体)ells. Inhib (显示 RPS6KA3 抗体)ition of RSK2 reduced the PDK (显示 ASF1A 抗体)1-induced cell invasion and cytokines secretion (显示 PDK1 抗体) in M (显示 RPS6KA3 抗体)H7A cells. In response to TNF-alpha, PDK1 could phosphorylate RSK2 and activated RSK2, then promoting the activation of NF-kappaB.
In cancer cells resistant to PI3Kalpha (显示 PIK3CA 抗体) inhibition, PDK1 (显示 PDK1 抗体) blockade restores sensitivity to these therapies. SGK1 (显示 SGK1 抗体), which is activated by PDK1 (显示 PDK1 抗体), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (显示 TSC2 抗体).
Results suggest that Ser (显示 SIGLEC1 抗体)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (显示 PDK1 抗体)-PKCtheta (显示 PRKCQ 抗体);-mediated T cell activation.
Elevated expression of PDK1 (显示 PDK1 抗体) was an independent negative prognostic factor of gastric carcinoma.
miR (显示 MLXIP 抗体)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (显示 PDK1 抗体).
our results offer significant insight into how PIK3CA (显示 PIK3CA 抗体) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 and TGFb (显示 TGFB1 抗体) signaling in advanced HNSCC patients with PIK3CA (显示 PIK3CA 抗体) amplification
PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of asymmetric cell division and the Notch (显示 NOTCH1 抗体)-dependent differentiation program.
Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.
PDK1 was highly expressed in synovia of collagen-induced-arthritis mice compared to control. The expressions of PDK1, p-PDK1, RSK2 (显示 RPS6KA3 抗体) and p-RSK2 (显示 RPS6KA3 抗体) were all up-regulated in CIA (显示 NCOA5 抗体) compared with normal. This indicated that PDK1/RSK2 (显示 RPS6KA3 抗体) may participate in inflammatory progress of RA.
PDK1 is required for Ca(2 (显示 CA2 抗体)+)-dependent platelet activation on stimulation of collagen receptor (显示 ITGA2 抗体) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.
In conclusion, we have identified that ARL15 acts as an insulin (显示 INS 抗体)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (显示 IRS1 抗体)/PDPK1/AKT (显示 AKT1 抗体) insulin (显示 INS 抗体) pathway by interacting with its GAP ASAP2 (显示 ASAP2 抗体) and activating PDPK1. This research may provide new insights into GTPase (显示 RACGAP1 抗体)-mediated insulin (显示 INS 抗体) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (显示 INS 抗体) sensitizati
Only when suboptimal doses of Akt (显示 AKT1 抗体)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (显示 NOTCH1 抗体) inhibition was seen. We conclude that the Akt (显示 AKT1 抗体) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (显示 AKT1 抗体) signaling.
Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (显示 NFKB1 抗体).
PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.
The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.
The authors show that loss of frataxin homolog (fh (显示 FXN 抗体)) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2 (显示 MYEF2 抗体)).
PDK1 is also a presynaptic protein, though it is distributed more broadly.
dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (显示 CDK7 抗体) 1, dPDK1
at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (显示 PIK3C3 抗体) (PI3K)
Piriformospora indica-stimulated growth response is mediated by a pathway consisting of the PLD-PDK1-OXI1 cascade.
PDK1 (显示 PDK1 抗体) undergoes autophosphorylation at several sites; mutation of Ser (显示 SIGLEC1 抗体)-276 to Ala resulted in enzyme with no detectable autophosphorylation; other sites important for autophosphorylation &/or activity were Asp (显示 ASIP 抗体)-167, Thr (显示 TRH 抗体)-176, & Thr (显示 TRH 抗体)-211
PDK1 (显示 PDK1 抗体) is a potent enhancer of PID (显示 MTA2 抗体) activity.
specific lipid signaling pathways converge on PTI1-2 via the PDK1-OXI1 axis
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes.
3-phosphoinositide-dependent protein kinase 1
, 3-phosphoinositide dependent protein kinase-1
, pkB kinase
, protein kinase B kinase
, PkB kinase like gene 1
, Pkb kinase
, ATP synthase c subunit
, ATP synthase lipid-binding protein, mitochondrial
, ATP synthase proteolipid P2
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)
, ATPase protein 9
, ATPase subunit C
, mitochondrial ATP synthase, subunit C (subunit 9)
, phosphoinositide dependent kinase 1
, phosphoinositide-dependent kinase 1
, protein kinase 61C
, serine/threonine protein kinase
, pyruvate dehydrogenase kinase 1
, pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial