anti-Cyclin D1 (CCND1) 抗体产品概述

Human Cyclin D1 (CCND1) interaction partners

1. Cyclin D1-dependent global transcriptional downregulation was associated with a reduced nascent transcription and an accumulation of promoter-proximal paused RNA polymerase II (Pol II) that colocalized with cyclin D1 in mantle cell lymphoma.

2. Data show when cells were treated with siRNA-dipeptidyl peptidase 8 (DPP8), the expression of cyclin D1, matrix metalloproteinases, secreted MMP2 and MMP9 was downregulated.

3. SOX11 regulation by the cell-cycle regulator cyclin D1 (CCND1) and the signal transducer and activator of transcription 3 (STAT3), in mantle cell lymphoma is reported.

4. LncRNA H19 positively regulated cyclin D1 expression through directly binding to let-7a in vascular smooth muscle cells.

5. High CCND1 expression is associated with recurrence in papillary urothelial bladder cancer.

6. An increased expression of gamma-H2Acapital HA, Cyrillic and CCND1 correlated with radiation dose, telomere shortening, patient age and concomitant pathology in Chernobyl survivors.

7. Cyclin D1 expression in >10% of positive cells was observed mostly in the clear cell RCC, while p57 expression in

8. Among the patients with low BRCA1 or CCND1 expression, the Activation group showed better overall survival than the Exhaustion group. Adjusted hazards ratios were 0.43 (95% CI: 0.20-0.93) in patients with a low BRCA1 level, and 0.39 (95% CI: 0.19-0.81) in patients with a low CCND1 level, respectively

9. CCND1, NSD2, and MAF gene rearrangements were estimated accurately by IHC, suggesting that conventional FISH assays can be replaced by IHC.

10. We found that tumor expression of cyclin D1 and p53 may predict RFS, whereas cyclin D1 and regional lymph node status are independent variables associated with OS in children with MPNST

11. Overexpression of CCND1 is associated with colorectal cancer.

12. Cyclin D1 expression is regulated by Hes3 in lung cancer cells.

13. Study results indicate that CCND1 amplification is associated with worse 15-year survival in ER-positive/lymph node negative/human epidermal growth factor receptor 2 negative, luminal A and luminal B types breast cancer patients. Moreover, luminal A CCND1-amplified tumors display gene expression changes consistent with a more aggressive phenotype.

14. CCND1 polymorphism rs9344 may not have a role in overall cancer susceptibility in Indian population

15. a role of cytoplasmic cyclin D1 in the control of MCL cell migration and invasion

16. Ectopic expression of SNHG1 inhibited miR-326 expression in nucleus pulposus cells and promoted CCND1 expression.

17. NVP-BEZ235-induced cyclin D1 and cyclin E1 degradation.

18. CycD1 may have prognostic significance in TNBC.

19. transcription factor c-Jun bound to the promoter region of human miR-374a and suppressed miR-374a in A549 and pc-9 cells while inducing it in SPCA-1 and H1975 cells. Increased levels of miR-374a appeared to serve a protective role by targeting CCND1 in early-stage non-small-cell lung cancer.

20. CyclinD1 is frequently expressed in neoplastic Langerhans cells in Langerhans cell histiocytosis. It is an efficient marker to differentiate neoplastic from reactive LC proliferation.

Mouse (Murine) Cyclin D1 (CCND1) interaction partners

1. The results report a novel Sonic Hedgehog (Shh)-initiated circuit that regulates proliferation through coordinated activation of Ccnd1 and forkhead box protein D1 (FOXD1)-mediated suppression of cyclin-dependent kinase inhibitor 1C (Cdkn1c).

2. The authors' findings establish a firm molecular link of multiaggressiveness among SCP3, NANOG, cyclin D1, and CDK4/6 and identify CDK4/6 inhibitors as actionable drugs for controlling SCP3(high) immune-refractory cancer.

3. myogenic differentiation is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion.

4. SALL2 is a negative regulator of cell proliferation, an effect mediated in part by repression of G1-S cyclins' expression.

5. These results indicate that dysbindin-1A may control the cyclin D1 function spatiotemporally and might contribute to better understanding of the pathophysiology of dysbindin-1-associated disorders.

6. Elevated expression of miR302-367 in endothelial cells inhibits developmental angiogenesis via CDC42/CCND1 mediated signaling pathways.

7. autophagic degradation machinery and cyclin D1 linked to liver tumorigenesis

8. Treatment of mice with established BCL1 leukemia using the scFv-targeted polymer conjugate leads to a markedly prolonged survival time of the experimental animals compared with the treatment using the free drug and the nontargeted polymer-pirarubicin conjugate.

9. results suggest that DGKdelta controls the down-regulation of cyclin D1 expression by attenuating the PKC signaling pathway for C2C12 myogenic differentiation

10. the focal adhesion component paxillin is a cytoplasmic substrate of Ccnd1.Cdk4.

11. Since miR-290 cluster miRNAs are the most dominant stem-cell-specific miRNAs, our results revealed an important cause for the absence of Cyclin D1 in mouse embryonic stem cells

12. beta-catenin and p65 are activated in separate cellular compartments during liver regeneration, with p65 activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin, cyclin D1 expression, and subsequent proliferation

13. Ablation of periostin suppresses post-infarction myocardial regeneration by inhibiting the PI3K/GSK3beta/cyclin D1 signalling pathway, indicating that periostin is essential for myocardial regeneration.

14. Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.

15. NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK and Akt and induction of D-type cyclins, cyclin D1 and D2.

16. Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.

17. our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.

18. identify Pax5 and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.

19. Data show that expression of the Oct-4, Sox2, Klf4, and c-Myc (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.

20. study shows that PLCgamma1 controls osteoclast numbers via a CSF-1-dependent DAG/beta-catenin/cyclinD1 pathway.

Zebrafish Cyclin D1 (CCND1) interaction partners

1. Methylparabens exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group.

2. while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of

3. show that the knockdown of smc1a in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels

4. Reduction of cyclin D1 expression compromises zebrafish eye and head development.

5. Role in cell cycle control is mediated by meis1 regulating cyclin D1 and c-myc transcription in the embryonic eye.

Xenopus laevis Cyclin D1 (CCND1) interaction partners

1. Results suggest that the TCF/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.

Cow (Bovine) Cyclin D1 (CCND1) interaction partners

1. CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.

2. cyclin D1, CDK2 and CDK4 are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation

3. 17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 kinase) pathway.