This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008].
Cloutier, Al-Khoury, Lavallée-Adam, Faubert, Jiang, Poitras, Bouchard, Forget, Blanchette, Coulombe: "High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes." in: Methods (San Diego, Calif.), Vol. 48, Issue 4, pp. 381-6, (2009) (PubMed).
Bouwmeester, Bauch, Ruffner, Angrand, Bergamini, Croughton, Cruciat, Eberhard, Gagneur, Ghidelli, Hopf, Huhse, Mangano, Michon, Schirle, Schlegl, Schwab, Stein, Bauer, Casari, Drewes, Gavin, Jackson et al.: "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. ..." in: Nature cell biology, Vol. 6, Issue 2, pp. 97-105, (2004) (PubMed).