Poly(rC) Binding Protein 1 (PCBP1) Peptide
PCBP1
适用: 人
宿主: 合成
BP, WB
-
- 抗原 See all PCBP1 products
- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
- 宿主
- 人
-
资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-PCBP1 antibody (Catalog #: ARP40630_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
-
-
- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- 抗原
- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
- 背景
-
PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
Alias Symbols: HNRPX, HNRPE1, hnRNP-X, hnRNP-E1
Protein Interaction Partner: CELF2,CELF3,EWSR1,GNB2,HNRNPD,HNRNPK,HNRPLL,LMNA,MATR3,NOVA1,PABPC1,PCBP2,PCBP4,PDLIM7,PTBP1,PUF60,QKI,RALY,RBM11,RBM42,SRSF3,TCERG1,TSC22D4,UGP2,ZNF384,RUVBL1,RUVBL2,TAF10,TCERG1
Protein Size: 356 - 分子量
- 39 kDa
- 基因ID
- 5093
- NCBI登录号
- NM_006196, NP_006187
- UniProt
- Q15365
-
You are here:
