PCBP1 产品
(Poly(rC) Binding Protein 1 (PCBP1))
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This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008].
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Featured PCBP1 Categories
PCBP1 抗体
High quality antibodies with extensive validation data.
PCBP1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PCBP1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PCBP1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC
Validations
- (1)
- (7)
Cat. No.
ABIN2778971
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (3)
Cat. No.
ABIN518653
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN6145277
Quantity
100 μL
Datasheet
Datasheet
Recommended PCBP1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969446
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1148571
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN1148569
Quantity
96 tests
Datasheet
Datasheet
Recommended PCBP1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124508
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314125
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314127
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PCBP1 Products
: "PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27." in: Molecular cancer research : MCR, Vol. 14, Issue 7, pp. 634-46, (2016) (PubMed).: "Establishing an in vivo p48ZnF bioluminescence mouse brain imaging model." in: Neuroscience letters, Vol. 542, pp. 97-101, (2013) (PubMed).
: "Global analysis reveals multiple pathways for unique regulation of mRNA decay in induced pluripotent stem cells." in: Genome research, Vol. 22, Issue 8, pp. 1457-67, (2012) (PubMed).
: "PCBP1 is required for maintenance of the transcriptionally silent state in fully grown mouse oocytes." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 15, pp. 2833-42, (2012) (PubMed).
: "Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest." in: The Journal of biological chemistry, Vol. 284, Issue 14, pp. 9039-49, (2009) (PubMed).
: "A cytosolic iron chaperone that delivers iron to ferritin." in: Science (New York, N.Y.), Vol. 320, Issue 5880, pp. 1207-10, (2008) (PubMed).
Synonyms and alternative names related to PCBP1
poly(rC) binding protein 1 (PCBP1), poly(rC) binding protein 1 L homeolog (pcbp1.L), poly(rC)-binding protein 1 (LOC100388387), poly(rC) binding protein 1 (Pcbp1), alphaCP-1, hnRNP-E1, hnRNP-X, hnRNP E1, HNRPE1, HNRPX, PCBP1, RGD1561319, WBP17, [a]CP-1Protein level used designations for PCBP1
- poly(rC) binding protein 1
- poly(rC)-binding protein 1-like
- alpha-CP1
- heterogeneous nuclear ribonucleoprotein E1
- heterogenous nuclear ribonucleoprotein E1
- heterogenous nuclear ribonucleoprotein X
- nucleic acid-binding protein SUB2.3
- poly(rC)-binding protein 1
- hnRNP-E1 protein
- hnRNP E1
- hnRNP-E1
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