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(Pyruvate Carboxylase (PC))
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This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
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Latest Publications for our PC Products
: "Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease." in: Chemico-biological interactions, Vol. 315, pp. 108907, (2020) (PubMed).: "Generation of Human Pyruvate Carboxylase Knockout Cell Lines Using Retrovirus Expressing Short Hairpin RNA and CRISPR-Cas9 as Models to Study Its Metabolic Role in Cancer Research." in: Methods in molecular biology (Clifton, N.J.), Vol. 1916, pp. 273-288, (2019) (PubMed).
: "Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1." in: Cell metabolism, Vol. 28, Issue 2, pp. 268-281.e4, (2018) (PubMed).
: "Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis." in: Nature cell biology, Vol. 17, Issue 10, pp. 1317-26, (2015) (PubMed).
: "Diet-induced obesity in the selenocysteine lyase knockout mouse." in: Antioxidants & redox signaling, Vol. 23, Issue 10, pp. 761-74, (2015) (PubMed).
: "Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 beta cells." in: Molecular and cellular endocrinology, Vol. 383, Issue 1-2, pp. 48-59, (2014) (PubMed).
: "Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice." in: Nature medicine, Vol. 20, Issue 11, pp. 1263-9, (2014) (PubMed).
: "Enhanced Ca(2+)-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model." in: Neurobiology of disease, Vol. 58, pp. 192-9, (2013) (PubMed).
: "Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism." in: PLoS pathogens, Vol. 7, Issue 7, pp. e1002124, (2011) (PubMed).
: "Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme." in: Science (New York, N.Y.), Vol. 317, Issue 5841, pp. 1076-9, (2007) (PubMed).
Synonyms and alternative names related to PC
Pyruvate carboxylase (PCB), pyruvate carboxylase b (pcxb), PYruvate Carboxylase (pyc-1), pyruvate carboxylase (PC), pyruvate carboxylase (pyc), pyruvate carboxylase Pyr1 (pyr1), pyruvate carboxylase (CNF00650), Pyruvate carboxylase (PYC1), pyruvate carboxylase (Ndas_1152), pyruvate carboxylase (Ilyop_2503), pyruvate carboxylase (Calni_0495), pyruvate carboxylase (Ftrac_1004), pyruvate carboxylase (Plabr_3574), pyruvate carboxylase (Sgly_2936), pyruvate carboxylase (Celly_0558), pyruvate carboxylase (Hipma_0131), pyruvate carboxylase (Halhy_1567), pyruvate carboxylase (Mesop_1269), pyruvate carboxylase (Pcx), pyruvate carboxylase (Pc), BA4157, BcDNA, BcDNA:GH06348, Dmel\\CG1516, PC, Pc, Pcb, PCB, PCX, Pcx, pyc, wu:fb82g08, wu:fj85g01Protein level used designations for PC
- CG1516-PA
- CG1516-PB
- CG1516-PD
- CG1516-PE
- CG1516-PG
- CG1516-PI
- CG1516-PJ
- CG1516-PK
- CG1516-PL
- CG1516-PM
- CG1516-PP
- GH06348
- pyruvate carboxykinase
- pyruvate carboxylase
- PYCb
- pyruvate carboxylase, mitochondrial
- PYruvate Carboxylase family member (pyc-1)
- Pyruvate carboxylase
- pyruvate decarboxylase
- pyruvic carboxylase
- PCB
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