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Poly(rC) Binding Protein 1 (PCBP1) (Middle Region) Peptide

PCBP1 适用: 人 宿主: 合成 BP, WB, IHC
产品编号 ABIN981427
发货至: 中国
  • 抗原 See all PCBP1 products
    PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
    蛋白结构域
    Middle Region
    宿主
    资源
    • 8
    合成
    应用范围
    Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    PHATHDLEGP PLDAYSIQGQ HTISPLDLAK LNQVARQQSH FAMMHGGTGF
    产品特性
    This is a synthetic peptide designed for use in combination with anti-PCBP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    纯化方法
    Purified
  • 应用备注
    Each Investigator should determine their own optimal working dilution for specific applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    浓度
    1 mg/mL
    缓冲液
    Final peptide concentration is 1 mg/mL in PBS.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • 抗原
    PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
    别名
    PCBP1 Peptide, HNRPE1 Peptide, HNRPX Peptide, hnRNP-E1 Peptide, hnRNP-X Peptide, hnRNP E1 Peptide, WBP17 Peptide, [a]CP-1 Peptide, alphaCP-1 Peptide, RGD1561319 Peptide, poly(rC) binding protein 1 Peptide, poly(rC) binding protein 1 L homeolog Peptide, poly(rC)-binding protein 1 Peptide, PCBP1 Peptide, pcbp1.L Peptide, LOC100388387 Peptide, Pcbp1 Peptide
    背景
    PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

    Alias Symbols: HNRPE1, HNRPX, hnRNP-E1, hnRNP-X

    Protein Size: 356
    分子量
    37 kDa
    基因ID
    5093
    NCBI登录号
    NM_006196, NP_006187
    UniProt
    Q15365
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