p53 蛋白
(Tumor Protein P53 (TP53))
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
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56 results :
custom-made
TP53
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
TP53
宿主: 人
宿主: 小麦胚
Recombinant
WB, ELISA, AP, AA
1 image
3 references
TP53
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
STD, PI, in vitro
Active
TP53
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
STD, AbP
2 references
TP53
宿主: 大鼠
宿主: 大肠杆菌（E. Coli）
Recombinant
Greater than 95 % as determined by SDS-PAGE
WB, ELISA
1 image
TP53
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
Greater than 90% as determined by SDS-PAGE.
ELISA
1 image
4 references
TP53
宿主: Cow
宿主: 大肠杆菌（E. Coli）
Recombinant
> 95 % as determined by reducing SDS-PAGE.
TP53
宿主: 小鼠
宿主: 大肠杆菌（E. Coli）
Recombinant
> 97 %
SDS, WB, Imm, PC
custom-made
TP53
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
Latest Publications for our p53 蛋白
: "The implication of autoantibodies in early diagnosis and monitoring of plasmonic photothermal therapy in the treatment of feline mammary carcinoma." in: Scientific reports, Vol. 11, Issue 1, pp. 10441, (2021) (PubMed).: "Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse." in: Scientific reports, Vol. 6, pp. 26187, (2016) (PubMed).
: "A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems." in: Journal of molecular biology, Vol. 428, Issue 20, pp. 4154-4167, (2016) (PubMed).
: "LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer." in: Journal of proteomics, Vol. 152, pp. 172-180, (2016) (PubMed).
: "A multiparametric serum marker panel as a complementary test to mammography for the diagnosis of node-negative early-stage breast cancer and DCIS in young women." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 23, Issue 9, pp. 1834-42, (2014) (PubMed).
: "Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 12, pp. 2367-79, (2012) (PubMed).
: "Characterization of the human p53 gene." in: Molecular and cellular biology, Vol. 6, Issue 5, pp. 1379-85, (1987) (PubMed).
: "Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells." in: The EMBO journal, Vol. 4, Issue 5, pp. 1251-5, (1985) (PubMed).
: "Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53." in: Molecular and cellular biology, Vol. 5, Issue 7, pp. 1601-10, (1985) (PubMed).
Aliases for p53 蛋白
tumor protein p53 (TP53) 蛋白cellular tumor antigen p53 (CpipJ_CPIJ002758) 蛋白
tumor protein p53 (Tp53) 蛋白
tumor protein p53 (tp53) 蛋白
transformation related protein 53 (Trp53) 蛋白
tumor protein p53 L homeolog (tp53.L) 蛋白
bbl 蛋白
BCC7 蛋白
bfy 蛋白
bhy 蛋白
brp53 蛋白
drp53 蛋白
etID22686.5 蛋白
fb40d06 蛋白
LFS1 蛋白
p44 蛋白
P53 蛋白
p53 蛋白
Tp53 蛋白
tp53 蛋白
TP53 蛋白
TRP53 蛋白
Trp53 蛋白
wu:fb40d06 蛋白
Xp53 蛋白
zgc:111919 蛋白
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