Patched 1 抗体
(Patched 1 (PTCH1))
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq, Jul 2008].
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Latest Publications for our Patched 1 抗体
: "Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo." in: International journal of cancer, Vol. 143, Issue 1, pp. 199-211, (2019) (PubMed).: "Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling." in: Experimental cell research, Vol. 371, Issue 2, pp. 417-425, (2018) (PubMed).
: "Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment." in: Biology of reproduction, Vol. 96, Issue 2, pp. 313-326, (2017) (PubMed).
: "Knockdown of HIF-1α inhibits the proliferation and migration of outer root sheath cells exposed to hypoxia in vitro: An involvement of Shh pathway." in: Life sciences, Vol. 191, pp. 82-89, (2017) (PubMed).
: "Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate." in: PLoS genetics, Vol. 12, Issue 10, pp. e1006352, (2016) (PubMed).
: "Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma." in: Molecular cancer therapeutics, Vol. 15, Issue 5, pp. 1095-105, (2016) (PubMed).
: "Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen." in: Experimental neurology, Vol. 271, pp. 493-505, (2015) (PubMed).
: "Developmental Status: Impact of Short-Term Ischemia on Follicular Survival of Whole Ovarian Transplantation in a Rabbit Model." in: PLoS ONE, Vol. 10, Issue 8, pp. e0135049, (2015) (PubMed).
: "Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling." in: Journal of neuro-oncology, Vol. 119, Issue 2, pp. 243-51, (2014) (PubMed).
: "High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma." in: OncoTargets and therapy, Vol. 7, pp. 79-86, (2014) (PubMed).
Aliases for Patched 1 抗体
patched 1 (PTCH1) 抗体patched 1 (ptch1) 抗体
patched 1 (Ptch1) 抗体
patched 1 L homeolog (ptch1.L) 抗体
Protein patched homolog 1 (ptc-1) 抗体
A230106A15Rik 抗体
BCNS 抗体
HPE7 抗体
lep 抗体
mes 抗体
NBCCS 抗体
patched 抗体
patched1 抗体
PTC 抗体
Ptc 抗体
Ptc-1 抗体
PTC1 抗体
ptc1 抗体
Ptc1 抗体
ptc2 抗体
PTCH 抗体
Ptch 抗体
Ptch2 抗体
PTCH11 抗体
XPtc1 抗体
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