PAI1 蛋白
(Plasminogen Activator Inhibitor 1 (SERPINE1))
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
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33 results
SERPINE1
宿主: 人
宿主: 小麦胚
Recombinant
WB, ELISA, AP, AA
1 image
1 reference
SERPINE1
宿主: 小鼠
宿主: 人细胞
Recombinant
> 95 % as determined by SDS-PAGE
1 image
SERPINE1
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
Greater than 95 % by SDS-PAGE gel analyses
WB, ELISA
1 image
SERPINE1
宿主: Pig
宿主: 大肠杆菌（E. Coli）
Recombinant
Greater than 95 % by SDS-PAGE gel analyses
WB, ELISA
1 image
SERPINE1
宿主: 小鼠
宿主: 大肠杆菌（E. Coli）
Recombinant
> 95 % as determined by reducing SDS-PAGE.
SERPINE1
宿主: 大鼠
宿主: 大肠杆菌（E. Coli）
Recombinant
> 95 % as determined by reducing SDS-PAGE.
SERPINE1
宿主: 大鼠
宿主: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SERPINE1
宿主: 小鼠
宿主: 大肠杆菌（E. Coli）
Recombinant
> 90 %
WB, SDS, Imm, PC
SERPINE1
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 97 % as determined by reducing SDS-PAGE.
Active
SERPINE1
宿主: 小鼠
宿主: 人细胞
Recombinant
> 95 % as determined by reducing SDS-PAGE.
SERPINE1
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
> 95 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD, Func, PI
Active
1 image
Latest Publications for our PAI1 蛋白
: "Components of the Plasminogen Activation System Promote Engraftment of Porous Polyethylene Biomaterial via Common and Distinct Effects." in: PLoS ONE, Vol. 10, Issue 2, pp. e0116883, (2015) (PubMed).: "Targeting of plasminogen activator inhibitor 1 improves fibrinolytic therapy for tetracycline-induced pleural injury in rabbits." in: American journal of respiratory cell and molecular biology, Vol. 52, Issue 4, pp. 429-37, (2015) (PubMed).
: "Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation." in: Blood, Vol. 125, Issue 8, pp. 1339-48, (2015) (PubMed).
: "A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage." in: Cellular signalling, Vol. 27, Issue 5, pp. 923-33, (2015) (PubMed).
: "Anti-tissue plasminogen activator (tPA) as an effective therapy of neonatal hypoxia-ischemia with and without inflammation." in: CNS neuroscience & therapeutics, Vol. 21, Issue 4, pp. 367-73, (2015) (PubMed).
: "The time course of resolution of adhesions during fibrinolyitic therapy in tetracycline-induced pleural injury in rabbits." in: American journal of physiology. Lung cellular and molecular physiology, pp. ajplung.00136.2015, (2015) (PubMed).
: "Inhibition of PAI-1 antiproteolytic activity against tPA by RNA aptamers." in: Nucleic acid therapeutics, Vol. 24, Issue 4, pp. 239-49, (2014) (PubMed).
: "SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence." in: Aging cell, Vol. 13, Issue 5, pp. 890-9, (2014) (PubMed).
: "Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex." in: Biochemistry, Vol. 52, Issue 27, pp. 4697-709, (2013) (PubMed).
: "Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 305, Issue 10, pp. L682-92, (2013) (PubMed).
Aliases for PAI1 蛋白
serpin family E member 1 (SERPINE1) 蛋白serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog (serpine1.L) 蛋白
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (serpine1) 蛋白
serine (or cysteine) peptidase inhibitor, clade E, member 1 (Serpine1) 蛋白
serpin family E member 1 (Serpine1) 蛋白
PAI 蛋白
PAI-1 蛋白
PAI1 蛋白
Pai1 蛋白
PAI1A 蛋白
Pai1aa 蛋白
Planh 蛋白
PLANH1 蛋白
Planh1 蛋白
RATPAI1A 蛋白
SERPINE1 蛋白
si:ch211-138a11.1 蛋白
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