This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. [provided by RefSeq, Jul 2008].
Bohdanowicz, Balkin, De Camilli, Grinstein: "Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling." in: Molecular biology of the cell, Vol. 23, Issue 1, pp. 176-87, (2012) (PubMed).