抗Mouse (Murine) Vitamin D Receptor 抗体:
抗Rat (Rattus) Vitamin D Receptor 抗体:
抗Human Vitamin D Receptor 抗体:
Chemical Polyclonal Vitamin D Receptor Primary Antibody for IF (p), IHC (p) - ABIN682513
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. in International journal of clinical and experimental pathology 2014
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Chemical Polyclonal Vitamin D Receptor Primary Antibody for IHC (p), WB - ABIN3043960
Gao, Wang, Yan, Zeng, Ma, Niu, Zhou, Jiang, Chen: Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats. in PLoS ONE 2016
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Chemical Polyclonal Vitamin D Receptor Primary Antibody for WB - ABIN3042969
Hou, Huang, Luo, Wang, Liu, Deng, Zhang, Liu, Chen: MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR. in American journal of translational research 2017
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Dog (Canine) Polyclonal Vitamin D Receptor Primary Antibody for ELISA, WB - ABIN547464
Malerba, Pignatti: A review of asthma genetics: gene expression studies and recent candidates. in Journal of applied genetics 2005
Human Monoclonal Vitamin D Receptor Primary Antibody for DB, WB - ABIN4251062
Momen-Heravi, Masugi, Qian, Nishihara, Liu, Smith-Warner, Keum, Zhang, Tchrakian, Nowak, Yang, Ma, Bowden, da Silva, Wang, Fuchs, Meyerhardt, Ng, Wu, Giovannucci, Ogino, Zhang: Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study. in International journal of cancer 2017
Chemical Polyclonal Vitamin D Receptor Primary Antibody for ELISA, WB - ABIN2477107
Cheng, Chen, Huang, Chang, Hung: Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex. in Journal of cellular biochemistry 2006
Chemical Monoclonal Vitamin D Receptor Primary Antibody for IHC (p) - ABIN2477108
Ditsch, Toth, Mayr, Lenhard, Gallwas, Weissenbacher, Dannecker, Friese, Jeschke: The association between vitamin D receptor expression and prolonged overall survival in breast cancer. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012
Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1(+)cMyb(+) HSPC numbers.
zebrafish embryos lacking vdrb produced fewer sensory hair cells in the ears and showed disruption of balance and motor coordination.
Taken together, these results suggest that VDR signaling plays an essential role in heart development.
investigation of binding of ligands that induce significant conformational changes at the protein level
The data suggest that VDR is widely distributed in tissues of the zebrafish, D. rerio, and is likely to play important roles in epithelial transport, bone, and endocrine function.
These results show that the VD3-VDR axis is critical to counteract GM-CSF-induced AM proliferation and defect in this regulation leads to altered AM homeostasis and function. Our findings identify that VD3 deficiency contributes to emphysema by altering AM function without contributing to bronchiolitis. Our findings also suggest possibilities of modulating the VD3-VDR axis for inhibiting emphysema in COPD patients.
this study shows that VDR is required for self-renewal, migration, and differentiation of epidermal stem cells and progeny during cutaneous wound healing
Niemann-Pick Type A Disease mice exhibited VDR gene and protein expression up-regulation.
Mice with VDR-deficiency showed spontaneous myocarditis that was characterized as the Th2-biased inflammation.
VDR binds NLRP3 to restrict IL4 gene transcription and prevent biased Th2 polarization.
Vitamin D Receptor in Energy Metabolism Revealed by Profiling of Lysine Succinylome of White Adipose Tissue
Recent studies suggest that in in inflammatory bowel diseases the association of VDR single nucleotide polymorphisms with immune and intestinal pathology may be sex dependent. [review]
While further studies are required to determine the mechanisms, by which vitamin D activity regulates osteoclastic bone resorption, our findings suggest that VDR-mediated activity in mature osteoclasts is required to moderate osteoclastic activity during growth and in ovariectomy-induced bone loss.
Our data indicate abnormal osteoclastogenesis due to the absence of Vdr expression, consistent with direct effects of vitamin D signalling being important for regulating the maturation and resorptive activities of osteoclasts.
We conclude that the relative VDR level and the 1,25D availability to cells, are important co-determinants for whether 1,25D plays a promoting or suppressive role in osteoblast-mediated osteogenic activity.
Taken together, our in vivo studies using ChIP-seq analyses and the mini-gene transgenic mice improve our understanding of the tissue-specific regulatory mechanisms of controlling VDR expression and the mechanisms of action of the VDR.
Low VDR expression is associated with epithelial-mesenchymal transition and metastasis in breast cancer.
These findings suggest that Vdr has a cell-intrinsic function in early erythroid progenitors.
Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex.
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms.
Data suggests that exposure to vitamin D deficiency during perinatal period directly affects expression of genes involved in development of adipose tissue in non-obese offspring; expression levels of Pparg (peroxisome proliferator activated receptor gamma) and Vdr (vitamin D receptor) are up-regulated in adipose tissue of male offspring.
The elevated levels of miR-351 promoted hepatic fibrosis by targeting the vitamin D receptor (VDR), which is an antagonist of SMAD signaling.
the crucial role of VDR in anti-inflammatory effects in lungs
In murine blood cells 1,25-Dihydroxyvitamin D, but not all-trans-retinoic acid, upregulates the expression of VDR.
These findings suggest that the vitamin D treatment-induced increase in bone mass is mediated by suppressing bone resorption through VDR in osteoblast-lineage cells.
The rs2228570 (FokI) variant was shown to have a significant association with decreased serum vitamin D levels in the Turkish Cypriot population.
Variants in hedgehog signaling pathway genes, such as GLI1 and PTCH1, and vitamin D receptor gene, might be considered as molecular risk factors in odontogenic cystic lesions
Higher maternal vitamin D Binding Protein level at delivery may decrease offspring T1 Diabetes (T1D) risk. Increased 25(OH)D levels at birth may decrease T1D risk, depending on VDR genotype.
This meta-analysis showed that polymorphisms in VDR ApaI, BsmI and FokI are not associated with psoriasis susceptibility in overall, Caucasian or Asian populations. However, the VDR TaqI polymorphism is associated with psoriasis susceptibility in Caucasian populations. [Meta-Analysis]
VDR decreases in actinic keratosis, not in a gradual manner but in the early steps of carcinogenesis.
Low VDR expression is associated with ulcerative colitis.
The CC genotype for the VDR gene FokI SNP was significantly more frequent in pulmonary tuberculosis patients than in controls in a Mexican population.
Significant associations between rs2228570 and PD risk were found in allelic, dominant, and additive models but not in recessive model. Stratified study revealed that rs2228570 was associated with PD susceptibility in Asian population, not in Caucasian population. Rs731236 was associated with increased PD risk in dominant model. No association was found between rs7975232 or rs1544410 and PD.
we demonstrate the association of VDR ApaI A allele, AA genotype, aa genotype, BsmI B allele, and Fok1 FF genotype are associated with the risk of renal cell carcinoma in Asians.
The f allele of FokI polymorphism in VDR gene is associated with an increased risk of inflammatory bowel disease and may be associated with a decreased risk of colon cancer based on case-control study of 695 colorectal cancer patients and 1397 controls, and meta-analysis of 27 studies.
VDR gene polymorphisms of ApaI and TaqI may have a role in the pathogenesis of acne vulgaris (AV) as A allele and AATT combined genotype could be considered protective against acne development and tt genotype and t allele may increase the risk of AV development in Egyptian patients. 25-hydroxyvitamin D3 deficiency can be considered as a risk factor for AV development.
Fok I (rs2228570) polymorphism in VDR gene confers susceptibility to community-acquired pneumonia (CAP) in study of Egyptian children.
It seems that the elevated AMH level is associated with VDR Fokl and Apal polymorphisms, but not with 25(OH)D levels in polycystic ovary syndrome(PCOS) women. Further research is needed to determine the role of VDR polymorphism in AMH level in PCOS.
SNPs of VDR gene (Apa-1 and Taq-1) were associated with the risk of DED. No significant association of Bsm-1 and Fok-1 in VDR gene demonstrated significant effect in the incidence of DED.
VDR polymorphisms are associated with susceptibility to development of heart failure in Chinese patients.
the transcriptomic response to 1,25-dihydroxyvitamin D in fibroblasts bearing a severe homozygous hereditary vitamin D resistant rickets-related p.Arg30* VDR mutation (MUT) and in control fibroblasts, was examined.
BB genotype of Vitamin D receptor gene (VDR) BsmI polymorphism is associated with an increased risk of Systemic lupus erythematosus (SLE) among Egyptian children. Oxidative stress may contribute in pathogenesis of SLE but is not associated with VDR BsmI polymorphism.
Although women with the "CC" VDR TaqI genotype had higher maternal and cord blood Pb levels, this was statistically insignificant.
Association analysis of the Fok (rs731236), Bsm (rs1544410), Apa (rs7975232), and Taq (rs731236) vitamin D receptor (VDR) gene polymorphisms indicated no difference in genotype or allele frequency according to serum vitamin D3 levels or clinical form of Chagas Disease. However, the serum levels of 25(OH)D3, but not of cathelicidin LL-37, were lower in the cardiac form group.
Meta analysis and systematic review of polymorphisms of vitamin D receptor and risk of adolescent idiopathic scoliosis susceptibility in Asian population.
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D receptor beta
, vitamin D receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor A
, nuclear receptor subfamily 1 group I member 1-A
, vitamin D3 receptor A
, Nuclear receptor subfamily 1 group I member 1
, protein phosphatase 1, regulatory subunit 163
, vitamin D nuclear receptor variant 1
, vitamin D receptor protein