抗Mouse (Murine) Vitamin D Receptor 抗体:
抗Rat (Rattus) Vitamin D Receptor 抗体:
抗Human Vitamin D Receptor 抗体:
Chemical Polyclonal Vitamin D Receptor Primary Antibody for IF (p), IHC (p) - ABIN682513
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. in International journal of clinical and experimental pathology 2014
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Chemical Polyclonal Vitamin D Receptor Primary Antibody for IHC (p), WB - ABIN3043960
Gao, Wang, Yan, Zeng, Ma, Niu, Zhou, Jiang, Chen: Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats. in PLoS ONE 2016
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Chemical Polyclonal Vitamin D Receptor Primary Antibody for WB - ABIN3042969
Hou, Huang, Luo, Wang, Liu, Deng, Zhang, Liu, Chen: MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR. in American journal of translational research 2017
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Dog (Canine) Polyclonal Vitamin D Receptor Primary Antibody for ELISA, WB - ABIN547464
Malerba, Pignatti: A review of asthma genetics: gene expression studies and recent candidates. in Journal of applied genetics 2005
Human Monoclonal Vitamin D Receptor Primary Antibody for DB, WB - ABIN4251062
Momen-Heravi, Masugi, Qian, Nishihara, Liu, Smith-Warner, Keum, Zhang, Tchrakian, Nowak, Yang, Ma, Bowden, da Silva, Wang, Fuchs, Meyerhardt, Ng, Wu, Giovannucci, Ogino, Zhang: Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study. in International journal of cancer 2017
Chemical Polyclonal Vitamin D Receptor Primary Antibody for ELISA, WB - ABIN2477107
Cheng, Chen, Huang, Chang, Hung: Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex. in Journal of cellular biochemistry 2006
Chemical Monoclonal Vitamin D Receptor Primary Antibody for IHC (p) - ABIN2477108
Ditsch, Toth, Mayr, Lenhard, Gallwas, Weissenbacher, Dannecker, Friese, Jeschke: The association between vitamin D receptor expression and prolonged overall survival in breast cancer. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012
Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1(+)cMyb(+) HSPC numbers.
zebrafish embryos lacking vdrb produced fewer sensory hair cells in the ears and showed disruption of balance and motor coordination.
Taken together, these results suggest that VDR signaling plays an essential role in heart development.
investigation of binding of ligands that induce significant conformational changes at the protein level
The data suggest that VDR is widely distributed in tissues of the zebrafish, D. rerio, and is likely to play important roles in epithelial transport, bone, and endocrine function.
this study shows that VDR is required for self-renewal, migration, and differentiation of epidermal stem cells and progeny during cutaneous wound healing
Niemann-Pick Type A Disease mice exhibited VDR gene and protein expression up-regulation.
Mice with VDR-deficiency showed spontaneous myocarditis that was characterized as the Th2-biased inflammation.
VDR binds NLRP3 to restrict IL4 gene transcription and prevent biased Th2 polarization.
Vitamin D Receptor in Energy Metabolism Revealed by Profiling of Lysine Succinylome of White Adipose Tissue
Recent studies suggest that in in inflammatory bowel diseases the association of VDR single nucleotide polymorphisms with immune and intestinal pathology may be sex dependent. [review]
While further studies are required to determine the mechanisms, by which vitamin D activity regulates osteoclastic bone resorption, our findings suggest that VDR-mediated activity in mature osteoclasts is required to moderate osteoclastic activity during growth and in ovariectomy-induced bone loss.
Our data indicate abnormal osteoclastogenesis due to the absence of Vdr expression, consistent with direct effects of vitamin D signalling being important for regulating the maturation and resorptive activities of osteoclasts.
We conclude that the relative VDR level and the 1,25D availability to cells, are important co-determinants for whether 1,25D plays a promoting or suppressive role in osteoblast-mediated osteogenic activity.
Taken together, our in vivo studies using ChIP-seq analyses and the mini-gene transgenic mice improve our understanding of the tissue-specific regulatory mechanisms of controlling VDR expression and the mechanisms of action of the VDR.
Low VDR expression is associated with epithelial-mesenchymal transition and metastasis in breast cancer.
These findings suggest that Vdr has a cell-intrinsic function in early erythroid progenitors.
Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex.
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms.
Data suggests that exposure to vitamin D deficiency during perinatal period directly affects expression of genes involved in development of adipose tissue in non-obese offspring; expression levels of Pparg (peroxisome proliferator activated receptor gamma) and Vdr (vitamin D receptor) are up-regulated in adipose tissue of male offspring.
The elevated levels of miR-351 promoted hepatic fibrosis by targeting the vitamin D receptor (VDR), which is an antagonist of SMAD signaling.
the crucial role of VDR in anti-inflammatory effects in lungs
In murine blood cells 1,25-Dihydroxyvitamin D, but not all-trans-retinoic acid, upregulates the expression of VDR.
These findings suggest that the vitamin D treatment-induced increase in bone mass is mediated by suppressing bone resorption through VDR in osteoblast-lineage cells.
Gut epithelial VDR signaling controls mucosal inflammation by suppressing epithelial cell apoptosis.
Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis
The purpose of this study was to compare VDR gene and protein expression in the forearm muscle between sarcopenic and non-sarcopenic individuals who have sustained distal radius fractures.
there is a significant relationship between the VDR gene, Apal and Bsml, polymorphisms and urinary tract infections in children
A significantly increased risk was found of nearly two-fold for the allele T and TT genotypes of rs731236, independently of other well recognized risk factors. The rs731236 polymorphism is associated with the risk of primary primary osteoarthritis of the knee in Mexican Mestizo population.
Mutation type in the VDR gene appears to be related to differences in the disease phenotype and response to treatment. Study of 4 children in 3 families.
VDR gene TaqI polymorphism may be related to bone mineral density (BMD). The tt genotype may have a protective effect on BMD particularly in ulcerative colitis patients.
No evidence that rs1544410 polymorphism in VDR gene is associated with rheumatoid arthritis in Pakistani patients.
ff genotype of FokI polymorphism was associated with colorectal cancer risk in Southern Iranian population.
vitamin D receptor gene FokI SNPs were independently associated with having gestational diabetes mellitus (GDM) in Turkish women. VDR gene FokI SNPs might contribute to insulin resistance of developing GDM
Association between VDR genetic variations and lung cancer [meta-analysis]
showed that miR-802 expression was enhanced in oral keratinocytes from vitamin D receptor (VDR)(-/-) mice, and an inverse correlation between VDR and miR-802 was found in human biopsy specimens of oral lichen planus
The polymorphism of Apa(rs7975232) locus of VDR gene is correlated with allergic rhinitis (AR) susceptibility. CC genotype may be a susceptible factor for AR patients, but there is no significant correlation between Fokpolymorphism and AR.
This case-control study of a Western Romanian population shows an association between vitamin D receptor (VDR) polymorphisms (FokI and BsmI) and chronic periodontitis susceptibility.
The association of single nucleotide polymorphisms of the vitamin D receptor with metabolic syndrome is reported in a Thai population.
The TaqI and FokI fragment length polymorphisms of vitamin-D receptor (VDR) significantly contributed to the risk of rheumatoid arthritis (RA).
Linkage disequilibrium was not detected between ApaI and TaqI VDR gene polymorphisms as in the case of serum vitamin D status in ALRTI patients versus apparent healthy children.
lncRNAs are identified that modulate the vitamin D receptor in breast cancer.
Low serum vitamin D or VDR-SNP is not a risk factor for PC in Egyptian patients. Recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer and improving overall survival should be carefully considered
Study results suggest that VDR TaqI genotype might be associated with CKD during inflammatory conditions caused by periodontal disease.
this study investigated but did not show a correlation between plasma vitamin D levels, ApaI, BsmI, FokI, and TaqI polymorphisms, and urothelial type bladder cancers in a Turkish population
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D receptor beta
, vitamin D receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor A
, nuclear receptor subfamily 1 group I member 1-A
, vitamin D3 receptor A
, Nuclear receptor subfamily 1 group I member 1
, protein phosphatase 1, regulatory subunit 163
, vitamin D nuclear receptor variant 1
, vitamin D receptor protein