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抗Human Splicing Factor 1 抗体:
抗Mouse (Murine) Splicing Factor 1 抗体:
抗Rat (Rattus) Splicing Factor 1 抗体:
Human Polyclonal Splicing Factor 1 Primary Antibody for ICC, IF - ABIN4355720
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
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Human Monoclonal Splicing Factor 1 Primary Antibody for ELISA, WB - ABIN948633
Crisci, Raleff, Bagdiul, Raabe, Urlaub, Rain, Krämer: Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins. in Nucleic acids research 2015
We provide new evidence of this involvement, describing a novel heterozygous non-sense NR5A1 (显示 NR5A1 抗体) mutation in a 46,XY-DSD (显示 FADS1 抗体) with polysplenia female proband and her father, who had hypospadias and asplenia.
Results identified a novel heterozygous NR5A1 (显示 NR5A1 抗体) mutation, c.274C>T p.(Arg92Trp), in three unrelated patients with 46,XX (ovo)testicular disorders of sex development (DSD (显示 FADS1 抗体)). Transcriptomics in patient-derived lymphocytes showed upregulation of MAMLD1 (显示 MAMLD1 抗体), a direct NR5A1 (显示 NR5A1 抗体) target previously associated with 46,XY DSD (显示 FADS1 抗体). This study proposes NR5A1 (显示 NR5A1 抗体) as a novel gene for 46,XX (ovo)testicular DSD (显示 FADS1 抗体).
The results raise the possibility that specific mutations in NR5A1 (显示 NR5A1 抗体) underlie testicular development in genetic females.
Manipulating steroidogenic factor-1 (SF-1 (显示 NR5A1 抗体)) and nucleotide exchange factor VAV-2 (VAV2 (显示 VAV2 抗体)) abundance in cultured adrenocortical carcinoma (ACC (显示 ACACA 抗体)) cells indicate that VAV2 (显示 VAV2 抗体) was a critical factor for SF-1 (显示 NR5A1 抗体)-induced cytoskeletal remodeling and invasion in culture and in vivo (chicken chorioallantoic membrane) models.
Ten novel heterozygous NR5A1 (显示 NR5A1 抗体) mutations were identified in 46,XY DSD (显示 FADS1 抗体) patients, including five nonsynonymous variants (p.Gly26Glu, p.Thr29Arg, p.Trp302Cys, p.Ala340Val, p.Leu358Pro), four stop-gain variants (p.Tyr211*, p.Cys247*, p.Tyr404*, p.Cys412*), and one frameshift variant (p.Glu395del)
this study identified a novel regulatory circuit for ovarian AMH (显示 AMH 抗体) production; specifically, through the coordinated interplay between FOXL2 (显示 FOXL2 抗体) and SF-1 (显示 NR5A1 抗体) that could control ovarian follicle development.
we show that a specific recurrent heterozygous missense mutation (p.Arg92Trp) in the accessory DNA-binding region of NR5A1 (显示 NR5A1 抗体) is associated with variable degree of testis development in 46,XX children and adults from four unrelated families
we review genetic data generated through large-scale sequencing approaches that are changing our view of how this system works, including the recently described recurrent NR5A1 (显示 NR5A1 抗体) p.R92W mutation associated with testis development in 46,XX children
SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3'-Splice-Site RNA
The NR5A1 (显示 NR5A1 抗体) p.Arg92Gln variant, which has thus far only been seen in a family with 46,XY Disorder of Sex Development, most likely contributes to the ovotesticular Disorder of Sex Development in this case.
SF1 directly contributes to the abnormal uterine gland morphogenesis.
Sf1 SUMOylation and Dax1 (显示 NR0B1 抗体) have roles in the physiological cessation of FAdE-mediated Sf1 expression and the resultant regression of the postnatal fetal cortex (X-zone)
we found that KLF6 (显示 KLF6 抗体) transcriptionally cooperates with NUR77 (显示 NR4A1 抗体) and SF1
SF1 in the ventromedial nucleus of the hypothalamus regulates age-dependent obesity.
Data suggest that Sf1 and c-jun interact and cooperate to activate the Fdx1 promoter in MA-10 (tumorigenic cell line) and TM3 (non-tumorigenic cell line) Leydig cells; such activation requires different regulatory elements located between -124 and -306 bp of Fdx1 promoter and involves recruitment of Sf1 to this region. (Sf1 = splicing factor 1; c-jun = proto-oncogene c-jun; Fdx1 = ferredoxin 1)
The results of the current study show that EB treatment from P25 (显示 CDK5R1 抗体) to P36 (显示 ANXA2 抗体) could not restore the number of kisspeptin-ir cells in the AVPV in agonadal SF-1 KO mice to numbers found in gonadally intact WT or EB-treated WT/OVX females
the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 (显示 GATA4 抗体) and SF-1 expression.
Results clearly indicate that SF-1 is involved in the regulation of LIPE (显示 LIPE 抗体) expression after activation of protein kinase A in adrenocortical cells.
SF-1 is involved in cell cycle regulation, neurogenesis, and neuronal migration via controlling the estrogen signaling for proper neocortical development.
SIRT1 (显示 SIRT1 抗体) Relays Nutritional Inputs to the Circadian Clock Through the Sf1 Neurons of the Ventromedial Hypothalamus.
The studies performed did not confirm the ability of the SF1 insulator to protect expression of reporter gene white from the chromosome position effect in transgenic lines.
RRM domain of Arabidopsis splicing factor (显示 SLU7 抗体) SF1 is important for pre-mRNA splicing of a specific set of genes
The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect.
mammalian branch point-binding protein
, transcription factor ZFM1
, zinc finger gene in MEN1 locus
, zinc finger protein 162
, adrenal 4 binding protein
, adrenal 4-binding protein
, fushi tarazu factor homolog 1
, nuclear receptor AdBP4
, steroid hormone receptor Ad4BP
, steroidogenic factor 1
, steroidogenic factor 1 nuclear receptor
, steroidogenic factor-1
, splicing factor 1
, splicing factor 1, isoform 1