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抗Mouse (Murine) NCOR1 抗体:
抗Rat (Rattus) NCOR1 抗体:
抗Human NCOR1 抗体:
Human Polyclonal NCOR1 Primary Antibody for ChIP, IP - ABIN188815
Dai, Hussain: NR2F1 disrupts synergistic activation of the MTTP gene transcription by HNF-4α and HNF-1α. in Journal of lipid research 2012
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Human Monoclonal NCOR1 Primary Antibody for IHC, ELISA - ABIN966640
Zhang, Yoon, Wong: JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). in Molecular and cellular biology 2005
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Human Monoclonal NCOR1 Primary Antibody for IHC, ELISA - ABIN969310
Atsumi, Tomita, Kiyoi, Naoe: Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo. in Biochemical and biophysical research communications 2006
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Human Polyclonal NCOR1 Primary Antibody for ICC, IF - ABIN407956
Nazha, Granner, Maloney, Odashiro, Antecka, Burnier: Aberrant nuclear repressor coreceptor 1 localization in human retinoblastoma. in Ophthalmic research 2013
Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis
Loss of NCOR1 is associated with Thyroid Cancer.
These studies support a model in which NCOR1/2 mediates direct Retinoic acid-dependent repression of Fgf8 (显示 FGF8 抗体) in caudal (显示 CAD 抗体) progenitors in order to control somitogenesis.
demonstrate that the binding of HDAC3 (显示 HDAC3 抗体) to IR nGREs in vivo is mediated through interaction with SMRT/NCoR1
GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1-HDAC3 (显示 HDAC3 抗体) repressing complex, which is indispensable for NF-kappaB (显示 NFKB1 抗体)/AP1 (显示 JUN 抗体)-mediated GC-induced tethered indirect transrepression in vitro
dexamethasone, a powerful regulator of metabolism and of adipocyte differentiation, confers this change in NCoR mRNA splicing in cultured adipocytes.
Phosphorylation-mediated recruitment switch of NCoR1 between nuclear receptor subsets provides a mechanism by which corepressors can selectively modulate liver energy metabolism during the fasting-feeding transition
NCOR1 protein levels were significantly reduced.
corepressor specificity exists in vivo and that nuclear receptor corepressor1 is the principal regulator of thyroid hormone (显示 PTH 抗体) action
NCOR1 interacts with Rev-Erbalpha (显示 NR1D1 抗体) to regulate circadian expression of Tshb (显示 TSHB 抗体) mRNA independent of thyroid hormone (显示 PTH 抗体).
these data indicate that interactions between NCoR1 and TR control a specific pathway involved in regulation of cholesterol metabolism and clearance.
Nuclear Receptor Corepressor 1 is an important transcriptional regulator that interacts with nuclear receptors and other transcription factors. Recent results have shown the presence of inactivating mutations or deletions of the nuclear receptor corepressor 1 gene in human tumors.
NCOR1 function declines with prostate cancer progression. Reduction in NCOR1 levels causes bicalutamide resistance in LNCaP cells and compromises response to bicalutamide in mouse prostate in vivo
USP44 (显示 USP44 抗体) contributes to N-CoR functions in regulating gene expression and is required for efficient invasiveness of triple-negative breast cancer cells.
PDCD2 (显示 PDCD2 抗体) and NCoR1 may act as tumor suppressors in Gastrointestinal stromal tumors cells through the Smad (显示 SMAD1 抗体) signaling pathway.
Data suggest that complexes of HDAC3-H1.3 with NCOR1 and NCOR2/SMRT accumulate on chromatin in synchronized HeLa cells in late G2 phase and mitosis; deacetylation activity of HDAC3 is activated via phosphorylation of Ser-424 by CK2 only in mitosis.
NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential.
loss of nuclear NCoR results in upregulation of a specific cancer-related genetic signature, and is significantly associated with malignant melanoma progression.
The co-localization of AML1 (显示 RUNX1 抗体)-ETO (显示 RUNX1T1 抗体) with the N-CoR co-repressor to be primarily on genomic regions distal to transcriptional start sites. (NcoR1)
Data suggest that direct interactions of HLCS (显示 HLCS 抗体) (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1) and HDAC1 (histone deacetylase 1 (显示 HDAC1 抗体)) contribute toward transcriptional repression of repeats, presumably increasing genome stability.
Low NCoR expression is associated with glioblastoma.
Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 (显示 TBL1XR1 抗体) complexes by unliganded thyroid hormone (显示 PTH 抗体) receptors in transcriptional repression during vertebrate development
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
nuclear receptor corepressor 1
, nuclear receptor co-repressor 1
, retinoid X receptor interacting protein 13
, retinoid X receptor-interacting protein 13
, N-Cor/SMRT corepressor Rip13
, N-Cor/SMRT corepressor, Rip13
, thyroid hormone- and retinoic acid receptor-associated corepressor 1