(Sperm Antigen with Calponin Homology and Coiled-Coil Domains 1 (SPECC1))
The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
DAgostino, Giordano: "A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma." in: Oncotarget, Vol. 2, Issue 12, pp. 1055-74, (2012) (PubMed).
Dagostino, Giordano: "NSP 5a3a: a potential novel cancer target in head and neck carcinoma." in: Oncotarget, Vol. 1, Issue 6, pp. 423-35, (2011) (PubMed).
Sang, Fath, Giordano: "A gene highly expressed in tumor cells encodes novel structure proteins." in: Oncogene, Vol. 23, Issue 58, pp. 9438-46, (2004) (PubMed).
Aliases for NSP5 抗体
sperm antigen with calponin homology and coiled-coil domains 1 (SPECC1) 抗体 sperm antigen with calponin homology and coiled-coil domains 1 (Specc1) 抗体 sperm antigen with calponin homology and coiled-coil domains 1 L homeolog (specc1.L) 抗体 sperm antigen with calponin homology and coiled-coil domains 1 (specc1) 抗体 cytospin-B (LOC100013871) 抗体 2810012G08Rik 抗体 B230396K10Rik 抗体 CYTSB 抗体 Cytsb 抗体 HCMOGT-1 抗体 HCMOGT1 抗体 NSP 抗体 RGD1309718 抗体 si:dkey-13b16.2 抗体 specc1 抗体 SPECC1 抗体