(Nuclear Receptor Subfamily 5, Group A, Member 2 (NR5A2))
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
Yumoto, Nguyen, Sablin, Baxter, Webb, Fletterick: "Structural basis of coactivation of liver receptor homolog-1 by β-catenin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 1, pp. 143-8, (2012) (PubMed).
Benod, Vinogradova, Jouravel, Kim, Fletterick, Sablin: "Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 41, pp. 16927-31, (2011) (PubMed).
Zhao, Wen, Zheng, Sun, Sun, Ni: "Action mechanism of Zuo Gui Yin Decoction's promotion on estradiol production in rats during the peri-menopausal period." in: Journal of ethnopharmacology, Vol. 134, Issue 1, pp. 122-9, (2011) (PubMed).
Aliases for NR5A2 + LRH1 抗体
nuclear receptor subfamily 5 group A member 2 S homeolog (nr5a2.S) 抗体 nuclear receptor subfamily 5 group A member 2 (NR5A2) 抗体 nuclear receptor subfamily 5 group A member 2 (nr5a2) 抗体 nuclear receptor subfamily 5 group A member 2 L homeolog (nr5a2.L) 抗体 nuclear receptor subfamily 5, group A, member 2 (Nr5a2) 抗体 AU020803 抗体 b1f 抗体 B1F 抗体 b1f2 抗体 B1F2 抗体 cpf 抗体 CPF 抗体 D1Ertd308e 抗体 ff1r 抗体 ftf 抗体 FTF 抗体 Ftf 抗体 ftz-f1 抗体 FTZ-F1 抗体 ftz-f1beta 抗体 FTZ-F1beta 抗体 hb1f 抗体 hb1f-2 抗体 hB1F-2 抗体 lrh-1 抗体 LRH-1 抗体 Lrh-1 抗体 lrh1 抗体 LRH1 抗体 NR5A2 抗体 UF2-H3B 抗体 xff1ra 抗体 xff1rashort 抗体 xFF1rB 抗体