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APH1A 抗体

(Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011].
APH1A 抗体  (AA 71-170) APH1A 抗体  (AA 71-170) APH1A 抗体 (AA 71-170) (ABIN706016)

APH1A 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

APH1A 抗体  (Internal Region) APH1A 抗体  (Internal Region) APH1A 抗体 (Internal Region) (ABIN190762)

Verified APH1A 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

APH1A 抗体  (C-Term) APH1A 抗体  (C-Term) APH1A 抗体 (C-Term) (ABIN7265628)

APH1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

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Find APH1A 抗体 for a variety of species such as anti-Human APH1A, anti-Mouse APH1A, anti-Rat APH1A. The species listed below are among those available. Click on a link to go to the corresponding products.

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Popular APH1A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (3)
Cat. No. ABIN706016
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN190762
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN7265628
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF
Validations
  • (1)
Cat. No. ABIN7153559
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application IF
Validations
  • (1)
Cat. No. ABIN7258038
Quantity 200 μL
Datasheet Datasheet
Reactivity Cow, Dog, Horse, Human, Monkey, Opossum
Application WB
Validations
  • (1)
Cat. No. ABIN960079
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN390272
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN499309
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN706018
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, FACS, IF (cc), IF (p)
Validations
Cat. No. ABIN883019
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, FACS, IF (cc), IF (p)
Validations
Cat. No. ABIN883020
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, FACS, IF (cc), IF (p)
Validations
Cat. No. ABIN883016
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, FACS, IF (cc), IF (p)
Validations
Cat. No. ABIN2809828
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, FACS, IF (cc), IF (p)
Validations
Cat. No. ABIN4996664
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, FACS, IF (cc), IF (p)
Validations
Cat. No. ABIN4996665
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our APH1A 抗体

Area-Gomez, de Groof, Boldogh, Bird, Gibson, Koehler, Yu, Duff, Yaffe, Pon, Schon: "Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria." in: The American journal of pathology, Vol. 175, Issue 5, pp. 1810-6, (2009) (PubMed).

Spasic, Raemaekers, Dillen, Declerck, Baert, Serneels, Füllekrug, Annaert: "Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway." in: The Journal of cell biology, Vol. 176, Issue 5, pp. 629-40, (2007) (PubMed).

Ma, Li, Price, Wong: "APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 1, pp. 192-8, (2005) (PubMed).

Periz, Fortini: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).

Takasugi, Tomita, Hayashi, Tsuruoka, Niimura, Takahashi, Thinakaran, Iwatsubo: "The role of presenilin cofactors in the gamma-secretase complex." in: Nature, Vol. 422, Issue 6930, pp. 438-41, (2003) (PubMed).

Marlow, Canet, Haugabook, Hardy, Lahiri, Sambamurti: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).

Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).

Gu, Chen, Sanjo, Kawarai, Hasegawa, Duthie, Li, Ruan, Luthra, Mount, Tandon, Fraser, St George-Hyslop: "APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7374-80, (2003) (PubMed).

Goutte, Tsunozaki, Hale, Priess: "APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 2, pp. 775-9, (2002) (PubMed).

Aliases for APH1A 抗体

aph-1 homolog A, gamma-secretase subunit (APH1A) 抗体
aph-1 homolog A, gamma secretase subunit L homeolog (aph1a.L) 抗体
aph-1 homolog A, gamma secretase subunit (Aph1a) 抗体
anterior pharynx defective 1 homolog A (C. elegans) (APH1A) 抗体
aph1 homolog A, gamma secretase subunit (Aph1a) 抗体
acylamino-acid-releasing enzyme-like (LOC100219182) 抗体
6530402N02Rik 抗体
APH-1 抗体
APH-1A 抗体
APH-1a 抗体
CGI-78 抗体
RGD1311546 抗体
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