This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008].
Smith, Kasper, Anastasio, Hommel: "Binge-Type Eating in Rats is Facilitated by Neuromedin U Receptor 2 in the Nucleus Accumbens and Ventral Tegmental Area." in: Nutrients, Vol. 11, Issue 2, (2019) (PubMed).
Kasper, Smith, Hommel: "Cocaine-Evoked Locomotor Activity Negatively Correlates With the Expression of Neuromedin U Receptor 2 in the Nucleus Accumbens." in: Frontiers in behavioral neuroscience, Vol. 12, pp. 271, (2018) (PubMed).
Kasper, McCue, Milton, Szwed, Sampson, Huang, Carlton, Meltzer, Cunningham, Hommel: "Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U." in: Biological psychiatry, (2016) (PubMed).
McCue, Kasper, Hommel: "Regulation of motivation for food by neuromedin U in the paraventricular nucleus and the dorsal raphe nucleus." in: International journal of obesity (2005), Vol. 41, Issue 1, pp. 120-128, (2016) (PubMed).