NMUR2 抗体 (Extracellular, N-Term)
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Quick Overview for NMUR2 抗体 (Extracellular, N-Term) (ABIN7043366)
抗原
See all NMUR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 3-16, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Neuromedin-U Receptor 2
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- 14 amino acid residues identical,Mouse -13, human - 7
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产品特性
- Anti-NMUR2 (extracellular) Antibody (ABIN7043366, ABIN7044706 and ABIN7044707) is a highly specific antibody directed against an epitope of the rat Neuromedin-U receptor 2. The antibody can be used in western blot and live cell imaging applications. It has been designed to recognize NMUR2 from rat, human, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KLENASWIHDPLMK, corresponding to amino acid residues 3-16 of rat NMUR2
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亚型
- IgG
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anti-Neuromedin U Receptor 2 (NMUR2) (C-Term) antibody
NMUR2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin U Receptor 2 (NMUR2) (Cytoplasmic Domain) antibodyNMUR2 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin U Receptor 2 (NMUR2) (N-Term) antibodyNMUR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin U Receptor 2 (NMUR2) (N-Term) antibodyNMUR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuromedin U Receptor 2 (NMUR2) antibodyNMUR2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:50
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236067)
Blocking Peptide: (ABIN7236067)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NMUR2 (Neuromedin U Receptor 2 (NMUR2))
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别名
- NMUR2
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背景
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Synonyms: Neuromedin-U receptor 2, NMU2 Receptor, G-protein coupled receptor TGR-1, G-protein coupled receptor FM-4, TGR1, GPR-FM4, SNORF72
Description: Neuromedin U (NMU) is a highly conserved, ubiquitously distributed neuropeptide, which regulates food intake and body weight. Two high-affinity receptors have been identified for NMU: Neuromedin U receptor 1 (NMUR1) and Neuromedin U receptor 2 (NMUR2) that belong to the G-protein coupled receptors (GPCRs). These receptors are members of the rhodopsin-like class A GPCR family and share about 50 % identity with each other in the seven transmembrane region.NMUR2 is highly expressed in the central nervous system, in the paraventricular nucleus of the hypothalamus, nuclei accumbens, hippocampus, thalamus, medulla oblongata, and spinal cord. It is also detected in organs such as the uterus and ovary, and is abundant in nociceptive sensory pathways, including spinal dorsal horn, dorsal root ganglia, thalamus, and brain stem1-5.Central effects of NMU, including the regulation of food intake, energy balance, stress response, and nociception, are mediated by NMUR2. In the brain, NMUR2 is predominant in the hypothalamic regions that are associated with regulation of food intake and energy balance5. NMUR2 has been suggested as a potential target for developing new therapeutics for the treatment of eating disorders, obesity, stress-related disorders, and pain5.Some studies have demonstrated that NMUR2 signaling in the paraventricular nucleus of the hypothalamus regulates consumption and preference for high-fat foods2.
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基因ID
- 64042
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NCBI登录号
- NM_020167
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UniProt
- Q9ESQ4
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途径
- Feeding Behaviour
抗原
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