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抗Human TRADD 抗体:
抗Mouse (Murine) TRADD 抗体:
抗Rat (Rattus) TRADD 抗体:
Human Monoclonal TRADD Primary Antibody for IF, IP - ABIN968046
He, Ting: A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. in Molecular and cellular biology 2002
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Human Monoclonal TRADD Primary Antibody for IF, IP - ABIN968045
Morgan, Thorburn, Pandolfi, Thorburn: Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms. in The Journal of cell biology 2002
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Human Monoclonal TRADD Primary Antibody for WB - ABIN967541
Hsu, Shu, Pan, Goeddel: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. in Cell 1996
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Human Monoclonal TRADD Primary Antibody for FACS, WB - ABIN4899051
Kolliputi, Waxman: IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. in American journal of respiratory cell and molecular biology 2009
Human Polyclonal TRADD Primary Antibody for IP, IHC - ABIN223257
Chen, Texada, Duggan, Liang, Reden, Kooragayala, Langford: Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells. in The Journal of biological chemistry 2005
Human Polyclonal TRADD Primary Antibody for IHC (p), IHC - ABIN407974
Chakraborty, Li, Tang, Xie, Puliyappadamba, Raisanen, Burma, Boothman, Cochran, Wu, Habib: Cytoplasmic TRADD confers a worse prognosis in glioblastoma. in Neoplasia (New York, N.Y.) 2013
Human Polyclonal TRADD Primary Antibody for IF (p), IHC (p) - ABIN673314
Chen, Zhang, Zhang, Li, Sun: Hydrogen sulfide protects against TNF-α induced neuronal cell apoptosis through miR-485-5p/TRADD signaling. in Biochemical and biophysical research communications 2016
These data for the first time identifies miR (显示 MLXIP 抗体)-485-5p/TRADD axis in hydrogen sulfide (显示 SQRDL 抗体) protecting against TNF-alpha (显示 TNF 抗体)-induced neuronal cell apoptosis.
By reducing the levels of TRADD, wild type CFTR suppresses downstream proinflammatory NFkappaB signaling.
NPM (显示 NPM1 抗体)-RAR (显示 RARA 抗体) binding to TRADD selectively inhibits caspase (显示 CASP3 抗体) activation, while allowing activation of NFkappaB (显示 NFKB1 抗体) and JNK (显示 MAPK8 抗体)
The release of extracellular vesicles was triggered by TNFA (显示 TNF 抗体) from BEAS-2b cells.TNFA-triggered extracellular vesicles contained TNFR1 (显示 TNFRSF1A 抗体) and TRADD.
MicroRNA-30c-2-3p negatively regulates NF-kappaB (显示 NFKB1 抗体) signaling and cell cycle progression through downregulation of TRADD and CCNE1 (显示 CCNE1 抗体) in breast cancer.
domains of calmodulin mediate FADD (显示 FADD 抗体) and TRADD interaction
PA induced the apoptosis of HUVECs by initiating the death pathway (TNF-R1 (显示 TNFRSF1A 抗体)/TRADD/caspases 8 pathway), whereas AA enhanced cell survival to protect vascular endothelial cells by activating the survival pathway (TNF-R1 (显示 TNFRSF1A 抗体)/RIP (显示 HRB 抗体)/NF-kappaB (显示 NFKB1 抗体) 50/NF-kappaB (显示 NFKB1 抗体) 65).
Biologic assessment found that NPM (显示 NPM1 抗体)-RAR (显示 RARA 抗体) expression impaired TNF (显示 TNF 抗体)-induced signaling through TRADD, blunting TNF (显示 TNF 抗体)-mediated activation of caspase-3 (CASP3 (显示 CASP3 抗体)) and caspase-8 (CASP8 (显示 CASP8 抗体)), to ultimately block apoptosis.
TRADD gene expression was knocked down by an antisense oligonucleotide.
structure-based mutations of TNFR-1 (显示 TNFRSF1A 抗体) (P367A and P368A), TRADD (F266A), and RIP1 (显示 UQCRFS1 抗体) (M637A and R638A) disrupted formation of the death domain (DD) complex and prevented stable interactions among those DDs
TRADD knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (显示 NR2C2 抗体)/p38 MAPK (显示 MAPK14 抗体) but not AKT (显示 AKT1 抗体) phosphorylation
Data indicate that ASK1 (显示 MAP3K5 抗体) activation stimulated the activity of the transcription factor FoxO3a (显示 FOXO3 抗体), which increased the abundance of the apoptosis-promoting adaptor protein TRADD, leading to activation of caspase 8 (显示 CASP8 抗体).
data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf (显示 CDKN2A 抗体)) and its E3 ubiquitin ligase (显示 MUL1 抗体) ULF (显示 TRIP12 抗体), thereby promoting p19(Arf (显示 CDKN2A 抗体)) protein stability and tumour suppression
Data suggest that deficiency of TRADD sensitizes cells to TRAIL-induced apoptosis, and that enhanced cell death in TRADD(-/-) MEFs is associated with defective NF-kappaB (显示 NFKB1 抗体) activation.
TRADD is required for recruitment of receptor interacting protein 1 (显示 RIPK1 抗体) and TNFR (显示 TNFRSF1A 抗体)-associated factor 2 to the DR3 (显示 TNFRSF25 抗体) signaling complex and for the ubiquitination of receptor interacting protein 1 (显示 RIPK1 抗体)
We show that TRADD is recruited to the TRAIL-receptor complex, and RIP1 (显示 RALBP1 抗体) recruitment is mediated by TRADD.
TRADD may be involved in IFN-gamma (显示 IFNG 抗体) signaling by forming a complex with STAT1 (显示 STAT1 抗体)-alpha within the nucleus and regulating IFN-gamma (显示 IFNG 抗体)-mediated STAT1 (显示 STAT1 抗体)-alpha activation.
Tradd activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm.
silencing TRADD expression with small-interfering RNA reduced neuronal apoptosis and subsequent microglial and astroglial activation
TRADD is a multifunctional protein crucial both for TNFR1 (显示 TNFRSF1A 抗体) signaling and other signaling pathways relevant to immune responses.
TNF (显示 TNF 抗体) binding induces release of AIP1 (DAB2IP (显示 DAB2IP 抗体)) from TNFR1 (显示 TNFRSF1A 抗体), resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1 (显示 RALBP1 抗体), TRAF2 (显示 TRAF2 抗体), and AIPl.
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.
TNFRSF1A-associated via death domain
, conjugal transfer protein D
, TNFR1-associated death domain protein
, tumor necrosis factor receptor type 1 associated death domain protein
, tumor necrosis factor receptor type 1-associated DEATH domain protein
, tumor necrosis factor receptor-1-associated protein
, TNF receptor 1 associated signal transducer
, TNFR1-associated DEATH domain protein
, Tumor necrosis factor receptor type 1-associated DEATH domain protein
, TNFRSF1A-associated via death domain protein