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The results suggest that cytokine-induced autophagy contributes to late-phase IkappaBalpha degradation, facilitates NF-kappaB nuclear translocation and VCAM-1 transcription for long-term VCAM-1 expression.
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NFKBIA SNP rs12883343, has a significantly different association with psoriatic arthritis than with cutaneous psoriasis in Chinese population.
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miR-196a-5p down-regulated IkBa expression while up-regulated nuclear p65 expression. Additionally, over-expression of IkBa in colorectal cancer cells attenuated the effects of miR-196a-5p on cell migration, invasion and epithelial-mesenchymal transition
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this study shows that disseminated Mycobacterium malmoense and Salmonella infections are associated with a novel variant in NFKBIA
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this study shows changes of NF-kB expression levels induced by cell-free DNA in different cell types
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the results of real-time PCR and western blotting revealed that Huaier extract decreased p65 and c-Met expression and increased IkappaBalpha expression, while paclitaxel increased p65 expression and reduced IkappaBalpha and c-Met expression.The molecular mechanisms may be involved in the inhibition of the NF-kappaB pathway and c-Met expression
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Colorectal cancer cases showed an increase in the frequency of NFkappaBIA-881G allele in Egyptian subjects.
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association between polymorphisms and progression of chronic hepatitis B Virus infection among Chinese Han Population
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miR-668 was upregulated in radioresistant human breast cancer cell lines MCF-7R and T-47DR, which targeted IkappaBalpha, activated the NF-kappaB pathway and thus increased the radioresistance of breast cancer cells.
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We showed that pristimerin suppressed tumor necrosis factor a (TNFalpha)-induced IkappaBa phosphorylation, translocation of p65, and expression of NFkappaB-dependent genes. Moreover, pristimerin decreased cell viability and clonogenic ability of Uveal melanoma (UM)cells. A synergistic effect was observed in the treatment of pristimerin combined with vinblastine, a frontline therapeutic agent, in UM.
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Data collectively demonstrate the functional importance of IkappaBalpha-mediated stripping of NFkappaB from DNA in the kinetic control of NFkappaB signaling.
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These findings indicate that genetic polymorphisms of NFKB1A rs696, pre-miR-146a rs2910164 and pre-miR-499 rs3746444 may represent novel markers of AT susceptibility.
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XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IkappaBalpha and overcomes acquired proteasome inhibitor resistance in human multiple myeloma.
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Molecular docking analysis indicated that transcription factor NF-kappaB was one of the potential molecular targets modulated by DTTF. Specifically, the drug blocked the TNFalpha-induced phosphorylation of upstream IkappaBalpha kinase in a time-dependent manner leading to the suppression of NF-kappaB activation and nuclear translocation
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FBXO32 activates NF-kappaB through IkappaBalpha degradation in inflammatory and genotoxic stress
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We show that HOTAIR regulates activation of NF-kB by decreasing Ik-Ba (NF-kB inhibitor) and establish that by inducing prolonged NF-kB activation and expression of NF-kB target genes during DNA damage, HOTAIR has a critical role in cellular senescence and platinum sensitivity
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The results showed that NFKB1 and NFKBIA single-nucleotide polymorphisms and gastric cancer are related and that the combined effects of polymorphisms in two genes and the NFKBIA gene monomer increased the risk of gastric cancer, and it was found that in different types of gastric cancer (the cardia and non-cardia cancer), susceptible polymorphism sites and combined effects are different.
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Double phosphorylation-induced structural changes in the signal-receiving domain of IkappaBalpha in complex with NF-kappaB have been described.
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Here, the authors report amide hydrogen/deuterium exchange data that reveal long-range allosteric changes in the NFkappaB (RelA-p50) heterodimer induced by DNA or IkappaBalpha binding.
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Sam68 is essential for DNA damage-induced NF-kappaB activation and colon tumorigenesis.