NFKBIA 抗体 (pSer32, pSer36)
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Quick Overview for NFKBIA 抗体 (pSer32, pSer36) (ABIN6256292)
抗原
See all NFKBIA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer32, pSer36
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特异性
- Phospho-I kappaB- alpha (Ser32/Ser36) Antibody detects endogenous levels of I kappaB- alpha only when phosphorylated at Serine 32/Serine 36
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human I kappaB- alpha around the phosphorylation site of Serine 32/Serine 36
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亚型
- IgG
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应用备注
- WB 1:500-1:2000 IHC 1:50-1:500 IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
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别名
- I kappaB alpha
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背景
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Description: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Gene: NFKBIA
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分子量
- 39kDa
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基因ID
- 4792
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UniProt
- P25963
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途径
- NF-kappaB Signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling
抗原
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