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Human Insulin Receptor Protein expressed in Human Cells - ABIN2003949
Kan, Kanai, Iida, Jinnouchi, Todaka, Imanaka, Ito, Nishioka, Ohnishi, Kamohara: Frequency of mutations of insulin receptor gene in Japanese patients with NIDDM. in Diabetes 1995
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INSR rs2252673 and rs3745546 polymorphisms were associated with sensitivity to platinum-based chemotherapy in epithelial ovarian cancer patients and rs2252673 polymorphism may be an independent risk factor for EOC prognosis.
The IGF1R (显示 IGF1R 蛋白) purified in n-dodecyl-beta-D-maltoside showed ligand-stimulated autophosphorylation and kinase activity, suggesting an intact transmembrane signaling mechanism.
Signaling via the insulin (INS (显示 INS 蛋白)) and insulin-like growth factor 1 (IGF1 (显示 IGF1 蛋白)) receptors (INSR and IGF1R (显示 IGF1R 蛋白)) regulate basal cell (BC) differentiation into ciliated cells.
High INSR expression is associated with drug Resistance in Gastrointestinal Stromal Tumors.
the above data indicate a direct role for IR expression as a determinant of PT-gluconeogenesis. Thus reduced insulin (显示 INS 蛋白) signaling of the proximal tubule may contribute to hyperglycemia in the metabolic syndrome via elevated gluconeogenesis.
Activation of D4 receptor inhibits insulin receptor expression in RPT cells from WKY rats. The aberrant inhibition of D4 receptor on insulin receptor expression and effect might be involved in the pathogenesis of essential hypertension.
The HIR MAb binds the insulin receptor on the BBB.
data indicate that post-receptor signalling abnormalities might contribute to Myotonic dystrophy insulin (显示 INS 蛋白) resistance regardless the alteration of INSR splicing.
We identified vascular INSR expression as a potential biomarker for progression in bladder cancer. The data suggest that IGF-2/INSR mediated paracrine crosstalk between bladder cancer cells and endothelial cells is functionally involved in tumour angiogenesis and may thus represent a new therapeutic target.
The INSR rs2059806 SNP is associated with pre-eclampsia phenotypes in two independent cohorts suggesting that genetic susceptibility may be implicated in the link between pre-eclampsia and subsequent vascular and metabolic diseases.
long-term hepatic expression of IRA could be a promising therapeutic approach for the treatment of type 2 diabetes mellitus.
the overlap of IR and IGF1R (显示 IGF1R 蛋白) signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (显示 FOXO3 蛋白)-regulated, autophagy-mediated protein degradation
These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon (显示 PRKCE 蛋白) and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin (显示 INS 蛋白) resistance.
Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.
Mice lacking the insulin receptor in AgRP (显示 AGRP 蛋白) neurons (AgRP (显示 AGRP 蛋白) IR KO) exhibited impaired hepatic insulin (显示 INS 蛋白) action because the ability of insulin (显示 INS 蛋白) to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin (显示 INS 蛋白) to suppress lipolysis was unaltered. To the contrary, in POMC (显示 POMC 蛋白) IR KO mice, insulin (显示 INS 蛋白) lowered hGP but failed to suppress adipose tissue lipolysis.
Intracellular retention of the insulin receptor is caused by elevated amounts of alpha-taxilin (显示 TXLNA 蛋白), a free syntaxin binding protein, in HBV expressing hepatocytes preventing proper targeting of the insulin receptor to the cell surface.
Results found that glioblastoma tumors resistant to PDGFR (显示 PDGFRB 蛋白) inhibition required the expression and activation of the insulin receptor (IR)/insulin (显示 INS 蛋白) growth-like factor receptor (IGF1R (显示 IGF1R 蛋白)) for tumor cell proliferation and survival.
The IR in the intestinal epithelium plays important roles in intestinal gene expression, glucose uptake, and GIP (显示 GIP 蛋白) production, which may contribute to pathophysiological changes in individuals with diabetes, metabolic syndrome, and other insulin (显示 INS 蛋白)-resistant states.
In conclusion, we have identified that ARL15 acts as an insulin (显示 INS 蛋白)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (显示 IRS1 蛋白)/PDPK1 (显示 PDPK1 蛋白)/AKT (显示 AKT1 蛋白) insulin (显示 INS 蛋白) pathway by interacting with its GAP ASAP2 (显示 ASAP2 蛋白) and activating PDPK1 (显示 PDPK1 蛋白). This research may provide new insights into GTPase (显示 RACGAP1 蛋白)-mediated insulin (显示 INS 蛋白) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (显示 INS 蛋白) sensitizati
Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a (显示 PPP2R2A 蛋白)). Inheritance of either allele results in insulin (显示 INS 蛋白) resistance but not overt diabetes. Double heterozygosity leads to insulin (显示 INS 蛋白) resistance and diabetes type 2 without increase in body weight.
INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper.
These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
Mactosylceramide, an early product in GSL (显示 CTSA 蛋白) biosynthesis, prevents inappropriate activation of insulin (显示 INS 蛋白) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.
Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress
results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep
This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.
The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.
InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation.
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.
studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (显示 IGF1 蛋白), IGF-2, IGFBP-2, IGFBP-3 (显示 IGFBP3 蛋白), IGF-1R (显示 IGF1R 蛋白), IGF-2R, GHR (显示 GHR 蛋白), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
FSH (显示 BRD2 蛋白), but not E2, stimulated the expression of IR and GHR (显示 GHR 蛋白) genes during follicular development.
Data conclude that insulin (显示 INS 蛋白) and IGF-I (显示 IGF1 蛋白) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila insulin receptor
, insulin receptor
, insulin receptor homolog
, insulin receptor homologue
, insulin-like receptor
, insulin receptor tyrosine kinase
, tyrosine kinase
, insulin receptor-like
, insulin receptor, beta-subunit