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Human Insulin Receptor Protein expressed in Human Cells - ABIN2003949
Kan, Kanai, Iida, Jinnouchi, Todaka, Imanaka, Ito, Nishioka, Ohnishi, Kamohara: Frequency of mutations of insulin receptor gene in Japanese patients with NIDDM. in Diabetes 1995
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the mechanism by which insulin (显示 INS 蛋白) induces IR translocation to the cell nucleus, was examined.
We conclude that the crosstalk between angiotensin AT1 receptor (显示 AGTRAP 蛋白) and insulin receptor signaling shows a high degree of specificity, and involves Galphaq (显示 GNAQ 蛋白) protein, and activation of distinct kinases. Thus, the BRET (显示 DNER 蛋白)(2) technique can be used as a platform for studying molecular mechanisms of crosstalk between insulin receptor and 7TM receptors.
INSR rs1051690 SNP is associated with increased risk of gastric cancer, while polymorphisms in IL12B (显示 IL12B 蛋白), CCND1 (显示 CCND1 蛋白) and IL10 (显示 IL10 蛋白) genes are not linked with the presence of gastric cancer
Findings demonstrate that, in human breast cancer cells, DDR1 (显示 DDR1 蛋白) regulates IR expression and ligand dependent biological actions. This novel functional crosstalk is likely clinically relevant.
in beta cells, INSR-B has a protective role, while INSR-A expression sensitizes beta cells to programmed cell death.
These results support the hypothesis that INSR gene expression in different areas of Alzheimer's patient's brains.
In endocrine-sensitive breast cancer cells, insulin (显示 INS 蛋白) was not growth stimulatory, likely due to the presence of hybrid InsR/IGF1R (显示 IGF1R 蛋白), which has high affinity for IGF-I (显示 IGF1 蛋白), but not insulin (显示 INS 蛋白). Combination inhibition of InsR and IGF1R (显示 IGF1R 蛋白) showed complete suppression of the system in endocrine-sensitive breast cancer cells
Report complex relationships between individual tumor-specific expression of IGF1R (显示 IGF1R 蛋白)/pIGF1R and InsR/pInsR, response endocrine treatment and breast cancer prognosis.
analysis of compounds that cause IGF-1Rbeta but not Insulin Receptor degradation specifically in tumor cells with no effects seen in normal diploid fibroblasts
The gained results are observed not only the unbinding mechanism of IRK (显示 KCNJ12 蛋白)-PTP1B (显示 PTPN1 蛋白) complexes came from pulling force profile, number of hydrogen bonds, and interaction energy between IRK (显示 KCNJ12 蛋白) and PTP1Bs but also described PTP1B's point mutations could variably change its binding affinity towards IRK (显示 KCNJ12 蛋白).
diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin (显示 INS 蛋白)/InsR and IGF-1 (显示 IGF1 蛋白)/IGF-1R (显示 IGF1R 蛋白) signaling. Insulin (显示 INS 蛋白) therapy in the early stage may delay diabetic gastroparesis
we show that glucagon receptor (GCGR (显示 GCGR 蛋白)) inhibition with a monoclonal antibody normalized blood glucose and beta-hydroxybutyrate levels. Insulin receptor antagonism increased pancreatic beta-cell mass threefold. Normalization of blood glucose levels with GCGR (显示 GCGR 蛋白)-blocking antibody unexpectedly doubled beta-cell mass relative to that observed with S961 alone and 5.8-fold over control
Data (including data from studies in knockout mice) suggest double knockout (DKO) mice lacking Insr and Igf1r (显示 IGF1R 蛋白) exhibit obesity with insulin (显示 INS 蛋白) resistance and increased adiposity; on high-fat diet, DKO mice exhibit metabolic syndrome. (Insr = insulin receptor; Igf1r (显示 IGF1R 蛋白) = insulin-like growth factor I receptor (显示 IGF1R 蛋白))
The data in this paper demonstrate that IR knockdown in primary tumors partially reverses the growth-promoting effects of hyperinsulinemia as well as highlighting the importance of the insulin receptor signaling pathway in cancer progression, and more specifically in epithelial-mesenchymal transition.
long-term hepatic expression of IRA could be a promising therapeutic approach for the treatment of type 2 diabetes mellitus.
the overlap of IR and IGF1R (显示 IGF1R 蛋白) signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (显示 FOXO3 蛋白)-regulated, autophagy-mediated protein degradation
These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon (显示 PRKCE 蛋白) and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin (显示 INS 蛋白) resistance.
Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.
Mice lacking the insulin receptor in AgRP (显示 AGRP 蛋白) neurons (AgRP (显示 AGRP 蛋白) IR KO) exhibited impaired hepatic insulin (显示 INS 蛋白) action because the ability of insulin (显示 INS 蛋白) to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin (显示 INS 蛋白) to suppress lipolysis was unaltered. To the contrary, in POMC (显示 POMC 蛋白) IR KO mice, insulin (显示 INS 蛋白) lowered hGP but failed to suppress adipose tissue lipolysis.
Impairment of insulin (显示 INS 蛋白) signalling in the mushroom body neurons, a structure involved in associative learning, impairs feeding behaviour in the Drosophila larva.[Insulin (显示 INS 蛋白)]
it was demonstrated that InR was expressed in follicular cells and that its expression in corpus allatum and follicular cells of Drosophila females was stage-specific, i.e., the expression intensity in young females greatly exceeded that in mature individuals.
INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper.
These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
Mactosylceramide, an early product in GSL (显示 CTSA 蛋白) biosynthesis, prevents inappropriate activation of insulin (显示 INS 蛋白) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.
Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress
results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep
This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.
The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.
studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (显示 IGF1 蛋白), IGF-2, IGFBP-2, IGFBP-3 (显示 IGFBP3 蛋白), IGF-1R (显示 IGF1R 蛋白), IGF-2R, GHR (显示 GHR 蛋白), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
FSH (显示 BRD2 蛋白), but not E2, stimulated the expression of IR and GHR (显示 GHR 蛋白) genes during follicular development.
Data conclude that insulin (显示 INS 蛋白) and IGF-I (显示 IGF1 蛋白) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila insulin receptor
, insulin receptor
, insulin receptor homolog
, insulin receptor homologue
, insulin-like receptor
, insulin receptor tyrosine kinase
, tyrosine kinase
, insulin receptor-like
, insulin receptor, beta-subunit