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抗Human MUC1 抗体:
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Human Polyclonal MUC1 Primary Antibody for IHC (p) - ABIN3043421
Wang, Du, Wang, Kuang, Wang: Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-kappaB pathway in primary rat microglia. in Acta pharmacologica Sinica 2010
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Human Monoclonal MUC1 Primary Antibody for ELISA, ICC - ABIN266893
Dalziel, Whitehouse, McFarlane, Brockhausen, Gschmeissner, Schwientek, Clausen, Burchell, Taylor-Papadimitriou: The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1. in The Journal of biological chemistry 2001
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Human Monoclonal MUC1 Primary Antibody for IHC (f), IHC (fro) - ABIN2689099
Agrawal, Schatz: RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. in Cell 1997
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Human Monoclonal MUC1 Primary Antibody for ICC, FACS - ABIN335355
Gourevitch, von Mensdorff-Pouilly, Litvinov, Kenemans, van Kamp, Verstraeten, Hilgers: Polymorphic epithelial mucin (MUC-1)-containing circulating immune complexes in carcinoma patients. in British journal of cancer 1995
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Human Polyclonal MUC1 Primary Antibody for ELISA, IHC - ABIN5693192
Zhang, Chen, Shi, Xie, Liu, Zhang, Lai, Zuo, Chen, Liu, Wang: Establishment of a new representative model of human ovarian cancer in mice. in Journal of ovarian research 2013
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Human Monoclonal MUC1 Primary Antibody for IHC (fro), IHC (p) - ABIN2479332
Kennedy, Darne, Cohn, Price, Davies, Blumsohn, Griffiths: Human chorionic gonadotropin may not be responsible for thyroid-stimulating activity in normal pregnancy serum. in The Journal of clinical endocrinology and metabolism 1992
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Human Monoclonal MUC1 Primary Antibody for FACS, IHC (fro) - ABIN2479333
Gill: Brittle diabetes: a report of the First International Conference on Brittle Diabetes. in Diabetic medicine : a journal of the British Diabetic Association 1992
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Human Monoclonal MUC1 Primary Antibody for IHC (fro), IHC (p) - ABIN3043642
Liu, Wei, Yang, Tan, Sun, Li, Che, Luan, Wang, Wang, Sun, Yin: Globose, cystic olfactory ensheathing cell tumor: A case report and literature review. in Oncology letters 2016
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we wanted to explore whether STAT3 can be related to lymph node micrometastasis of non-small cell lung cancer (NSCLC). To address this question, we evaluated the expression of MUC1 mRNA in the lymph node samples of NSCLC to determine micrometastasis. Then, we evaluated what role STAT3 overexpression plays in lymph node micrometastasis of NSCLC.
these data showed that sustained abnormal MUC1 induction accompanies failing epithelial repair, chronic inflammation and kidney fibrosis. In conclusion, MUC1 exerts opposite effects during kidney response to IR: first protective and then harmful
The expression profile of studied Mucins MUC16 and MUC1 and truncated O-glycans was not associated with the site of origin of ovarian cancer (OVCA) cell lines
MUC1 contributes to immune escape in an aggressive form of triple-negative breast cancer.MUC1 drives PD-L1 expression in triple-negative breast cancer cells.
Results show MUC1 expression highly expressed at mRNA and protein levels in esophageal squamous cell carcinoma (ESCC). MUC1 expression correlated with tumor invasion, lymph node metastasis, and TNM staging.
Correlation was also observed in the % change of CA 15-3 and CA 27.29 results between consecutive specimens for individual patients. Using doubling or halving thresholds (i.e., 100% increase or 50% decrease), concordance in % change was observed between CA 15-3 and CA 27.29 in approximately 90% of cases. Individual patient results trended similarly across both markers over time
Decreased expression of MUC1 is an independent marker for endometrial receptivity in recurrent implantation failure.
The glycosylation level of CA153 was found to increase with increasing breast cancer stage in the sandwich assay. The assay system appeared to efficiently discriminate breast cancer stage I (sensitivity: 63%, specificity: 69%), IIA (sensitivity: 77%, specificity: 75%), IIB (sensitivity: 69%, specificity: 86%) and III (sensitivity: 80%, specificity: 65%) from benign breast disease.
High MUC1 expression is associated with cervical cancer.
KL-6 is an accurate biomarker for the diagnosis of interstitial lung disease in systemic sclerosis.
MUC1 was a potential molecular target may help explain the role of lincRNA-ROR/miR-145 for invasion and metastasis in Triple-negative breast cancer cell lines.
We have analysed the tumour-associated carbohydrate antigens sialyl-Lewis x (SLe(x)) and sialyl-Tn (STn) on MUC1 and MUC5AC in Pancreatic adenocarcinoma (PDAC)tissues. immunoprecipitation of MUC5AC from positive PDAC tissues and subsequent SLe(x) immunodetection confirmed the presence of SLe(x) on MUC5AC. Altogether, MUC5AC-SLe(x) glycoform is present in PDAC and can be regarded as potential biomarker.
High MUC1 expression is associated with breast cancer metastasis.
These results revealed that serum WFA-sialylated MUC1 was associated with histological features of hepatocellular carcinoma and recurrence after curative therapy.
this study shows that basaloid squamous cell carcinoma and basal cell carcinoma of the head and neck can be readily distinguished by a limited panel consisting primarily of EMA, and supported by SOX2 and p16
In the in vitro tests, JFD-WS effectively inhibited HUVEC proliferation, migration, tube formation and VEGFR2 phosphorylation. Additionally, JFD-WS inhibited the formation of blood vessels in chick chorioallantoic membrane. While inhibiting the xenograft tumor growth in experimental mice, JFD-WS decreased the plasma MUC1 levels
Quercetin suppressed breast cancer stem cell proliferation, self-renewal, and invasiveness. It also lowered the expression levels of proteins related to tumorigenesis and cancer progression, such as aldehyde dehydrogenase 1A1, C-X-C chemokine receptor type 4, mucin 1, and epithelial cell adhesion molecules.
the proposed ECL immunosensor opened a new era for sensitive CA15-3 evaluation and offered a promising platform for clinical breast cancer diagnostics.
MUC1-mediated nucleotide metabolism plays a key role in facilitating radiation resistance in pancreatic cancer and targeted effectively through glycolytic inhibition
These findings indicate that decitabine intensifies MUC1-C inhibition induced redox imbalance and provides a novel combination of targeted and epigenetic agents for patients with Cutaneous T-cell lymphoma
The results indicate that Muc1 gene is significantly associated with litter size in pigs.
Adhesion between Lactococcus lactis, the model for lactic acid bacteria (LAB) and mucins, is reported.
The epiblast expressed epithelial markers, MUC1 and E-CADHERIN, and the pluripotency markers, DNMT3B and CRIPTO.
Endometrial expressions of MUC1 and cytokine genes differed among normal, fertile versus diseased, and subfertile dairy cows.
Bovine Muc1 prevents binding of bacteria to human intestinal cells and may have a role in preventing the binding of common enteropathogenic bacteria to human intestinal epithelial surfaces.
concluded that bovine Muc1 protein is probably an inducible innate immune effector and an important component of the first line of defense against bacterial invasion of epithelial surfaces
The results showed that co-administration of an adjuvant plasmid and a DNA vaccine stimulated the production of higher titers of specific antibodies and a T cell response and suppressed the growth of subcutaneous tumors expressing MUC1.
MUC1 plays an important role in protection against severe pneumococcal disease, potentially mediated by facilitating macrophage phagocytosis.
this study implicates the MUC1 as a critical and dynamic component of the innate host response that limits the severity of influenza and provides the foundation for exploration of MUC1 in resolving inflammatory disease
Tumor growth delays observed by tumor irradiation combined with MVA-MUC1-IL-2 vaccine were significantly more prolonged than those observed by vaccine, radiation, or radiation with MVA empty vector.
Muc1 has anti-fibrotic properties in the mouse lung.
our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1-dependent VEGFR signaling in PDA cells.
Low expression of MUC1 is associated with lung carcinogenesis.
Using an extensive collection of novel murine cell lines we have identified distinct roles for Kras and Pten on MUC1 and EMT in vivo and in vitro. The data has implications for future design of combination therapies targeting Kras mutations, Pten deletions and MUC1 vaccines.
Gp91phox NADPH oxidase modulates litter size by up-regulating mucin1 expression in the uterus of mice.
In summary, we have demonstrated that MUC1 on immune cells is a novel regulator of the NLRP3 inflammasome, and propose this is mediated by an interaction with signalling components at the cytoplasmic domains of TLRs that involves inhibition of IRAK4 activation.
MUC1 regulates IL-1beta secretion induced by the NLRP3-activating bacteria Haemophilus influenzae but not bacteria that activate other inflammasomes.
Muc1 protection during acute kidney injury proceeds by enhancing both the HIF-1 and beta-catenin protective pathways.
MAMs MUC1 and MUC16 contribute to the maintenance of immune homeostasis at the ocular surface by limiting TLR-mediated innate immune responses.
the present study provides evidence that Muc1 is a direct target of let-7a and let-7b in mouse uteri during embryo implantation.
Anatomical site-specific Cre-loxP recombination throughout the genital tract of MUC1KrasPten mice leads to MUC1 positive genital tract tumors, and the development of these tumors is influenced by the anatomical environment
Muc1 clearly plays a significant role in enhancing the hypoxia-inducible transcription factors protective pathway during ischemic insult and recovery in kidney epithelia
Epithelial Muc1 is important for gastric mucosa healing by enhancing cell migration and proliferation.
the present study provides evidence that MUC1 is a direct target of miRNA-199a during embryo implantation.
Helicobacter pylori infection is the most definite insult leading to gastric cancer, and a protective function of mucin 1 protein has been suggested by studies on Muc1 knocked-out mice.
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
, H23 antigen
, breast carcinoma-associated antigen DF3
, cancer antigen 15-3
, carcinoma-associated mucin
, krebs von den Lungen-6
, mucin 1, transmembrane
, peanut-reactive urinary mucin
, polymorphic epithelial mucin
, tumor associated epithelial mucin
, tumor-associated epithelial membrane antigen
, tumor-associated mucin
, endometrial mucin-1
, epithelial mucin