(NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9))
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (By similarity).
König, Probst-Kepper, Reinl, Jeron, Huehn, Schraven, Jänsch: "First insight into the kinome of human regulatory T cells." in: PLoS ONE, Vol. 7, Issue 7, pp. e40896, (2012) (PubMed).
Tan, Lee: "Nek9, a novel FACT-associated protein, modulates interphase progression." in: The Journal of biological chemistry, Vol. 279, Issue 10, pp. 9321-30, (2004) (PubMed).
Belham, Roig, Caldwell, Aoyama, Kemp, Comb, Avruch: "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases." in: The Journal of biological chemistry, Vol. 278, Issue 37, pp. 34897-909, (2003) (PubMed).
Roig, Mikhailov, Belham, Avruch: "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression." in: Genes & development, Vol. 16, Issue 13, pp. 1640-58, (2002) (PubMed).
Aliases for NEK9 抗体
NIMA related kinase 9 (NEK9) 抗体 NIMA-related kinase 9 (nek9) 抗体 NIMA related kinase 8 (NEK8) 抗体 NIMA related kinase 9 (nek9) 抗体 NIMA (never in mitosis gene a)-related expressed kinase 9 (Nek9) 抗体 NIMA-related kinase 9 (Nek9) 抗体 NIMA-related kinase 9 L homeolog (nek9.L) 抗体 NIMA related kinase 9 (Nek9) 抗体 C130021H08Rik 抗体 Nek8 抗体 NEK9 抗体 NERCC 抗体 nercc 抗体 NERCC1 抗体 nercc1 抗体