This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009].
Harrington, Clevenger: "Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration." in: The Journal of biological chemistry, Vol. 291, Issue 41, pp. 21388-21406, (2016) (PubMed).
McHale, Tomaszewski, Puthiyaveettil, Livolsi, Clevenger: "Altered expression of prolactin receptor-associated signaling proteins in human breast carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 21, Issue 5, pp. 565-71, (2008) (PubMed).
Kimura, Okano: "Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3)." in: Cytogenetics and cell genetics, Vol. 95, Issue 3-4, pp. 177-82, (2002) (PubMed).
Aliases for NEK3 抗体
NIMA related kinase 3 (NEK3) 抗体 NIMA (never in mitosis gene a)-related expressed kinase 3 (Nek3) 抗体 NIMA-related kinase 3 S homeolog (nek3.S) 抗体 NIMA-related kinase 3 (Nek3) 抗体 NIMA-related kinase 3 (NEK3) 抗体 ATNEK3 抗体 HSPK36 抗体 NIMA-RELATED KINASE3 抗体 NIMA-related kinase 3 抗体 T8M17.60 抗体 T8M17_60 抗体