NCF4 产品
(Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
Categories
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Featured NCF4 Categories
Recommended NCF4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7442450
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
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Validations
- (4)
Cat. No.
ABIN190755
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
ABIN7268900
Quantity
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Datasheet
Datasheet
Recommended NCF4 蛋白
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7556795
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7549637
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124162
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our NCF4 Products
: "Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. ..." in: Nature genetics, Vol. 39, Issue 5, pp. 596-604, (2007) (PubMed).Synonyms and alternative names related to NCF4
neutrophil cytosolic factor 4 (ncf4), neutrophil cytosolic factor 4 (Ncf4), neutrophil cytosolic factor 4 (NCF4), AI451400, NCF, p40phox, P40PHOX, SH3PXD4Protein level used designations for NCF4
- p40phox protein
- neutrophil cytosolic factor 4
- NADPH oxidase cytosolic protein p40phox
- NCF-4
- neutrophil NADPH oxidase factor 4
- neutrophil cytosol factor 4
- p40-phox
- SH3 and PX domain-containing protein 4
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