This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].
Dortet, Mostowy, Samba-Louaka, Louaka, Gouin, Nahori, Wiemer, Dussurget, Cossart: "Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy." in: PLoS pathogens, Vol. 7, Issue 8, pp. e1002168, (2011) (PubMed).
Aliases for MVP 蛋白
major vault protein (MVP) 蛋白 major vault protein (Mvp) 蛋白 major vault protein (mvp) 蛋白 major vault protein L homeolog (mvp.L) 蛋白 major vault protein (Tc00.1047053510353.10) 蛋白 major vault protein (Tb927.5.4460) 蛋白 major vault protein (Tb10.70.0520) 蛋白 major vault protein (Tb10.70.5840) 蛋白 putative major vault protein (LMJF_05_0060) 蛋白 2310009M24Rik 蛋白 cb771 蛋白 LRP 蛋白 MGC145641 蛋白 mvp 蛋白 Tb05.45E22.810 蛋白 VAULT1 蛋白 wu:fb52b05 蛋白 wu:fc02g01 蛋白