Metabotropic Glutamate Receptor 5 产品
(Glutamate Receptor, Metabotropic 5 (GRM5))
Categories
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].
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Featured Metabotropic Glutamate Receptor 5 Categories
Metabotropic Glutamate Receptor 5 抗体
High quality antibodies with extensive validation data.
Metabotropic Glutamate Receptor 5 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Metabotropic Glutamate Receptor 5 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Metabotropic Glutamate Receptor 5 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, ICC, FACS, Neut
Validations
- (6)
Cat. No.
ABIN5611178
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF, ICC, LCI
Validations
- (5)
Cat. No.
ABIN7043250
Quantity
25 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, PLA
Validations
- (3)
Cat. No.
ABIN516205
Quantity
100 μg
Datasheet
Datasheet
Recommended Metabotropic Glutamate Receptor 5 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967067
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1142179
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1142181
Quantity
96 tests
Datasheet
Datasheet
Recommended Metabotropic Glutamate Receptor 5 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355782
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3081171
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3122201
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Metabotropic Glutamate Receptor 5 Products
: "Autism-associated Shank3 mutations alter mGluR expression and mGluR-dependent but not NMDA receptor-dependent long-term depression." in: Synapse (New York, N.Y.), Vol. 73, Issue 8, pp. e22097, (2019) (PubMed).: "Synaptic integration of newly generated neurons in rat dissociated hippocampal cultures." in: Molecular and cellular neurosciences, Vol. 47, Issue 3, pp. 203-14, (2011) (PubMed).
: "The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption." in: Nature medicine, Vol. 11, Issue 1, pp. 35-42, (2005) (PubMed).
: "Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation." in: The Journal of biological chemistry, Vol. 279, Issue 32, pp. 33352-8, (2004) (PubMed).
: "Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 2254-61, (2004) (PubMed).
: "Differential expression of mGluR5 in human lumbosacral motoneurons." in: Neuroreport, Vol. 15, Issue 2, pp. 271-3, (2004) (PubMed).
Synonyms and alternative names related to Metabotropic Glutamate Receptor 5
glutamate receptor, metabotropic 5 (GRM5), glutamate metabotropic receptor 5 (GRM5), glutamate metabotropic receptor 5 (Grm5), glutamate receptor, metabotropic 5 (Grm5), 6430542K11Rik, AI850523, Glu5R, GPRC1E, Gprc1e, mGlu5, MGLUR5, mGluR5, mGlur5, mGluR5bProtein level used designations for Metabotropic Glutamate Receptor 5
- metabotropic glutamate receptor 5
- metabotropic glutamate receptor 5 variant F
- metabotropic glutamate receptor 5 variant G
- metabotropic glutamate receptor 5 variant H
- metabotropic glutamate receptor (mGluR5)
- metabotropic glutamate receptor 5b
- G protein coupled receptor, family C, group 1, member E
- G protein-coupled receptor GRM5
- G protein-coupled receptor, family C, group 1, member E
- metabotropic glutamate receptor subtype 5b
- metabotropic glutamate receptor type 5
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