MED12 抗体
(Mediator Complex Subunit 12 (MED12))
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].
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42 results
MED12
适用: 人, 小鼠, 大鼠, Cow, 犬, Pig
IHC, WB, IHC (p), IP, IF
宿主: 兔
Polyclonal
unconjugated
MED12
适用: 人, 小鼠
IHC, WB, IP, ICC
宿主: 兔
Monoclonal
BLR084G
unconjugated
Recombinant Antibody
Latest Publications for our MED12 抗体
: "H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas." in: Oncogene, Vol. 38, Issue 27, pp. 5356-5366, (2019) (PubMed).: "Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6." in: Journal of medicinal chemistry, Vol. 59, Issue 19, pp. 9124-9139, (2016) (PubMed).
: "Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 15, pp. 6679-90, (2013) (PubMed).
: "Temporal association of herpes simplex virus ICP4 with cellular complexes functioning at multiple steps in PolII transcription." in: PLoS ONE, Vol. 8, Issue 10, pp. e78242, (2013) (PubMed).
: "Distinct alternative splicing patterns of mediator subunit genes during endothelial progenitor cell differentiation." in: Biochimie, Vol. 94, Issue 8, pp. 1828-32, (2012) (PubMed).
: "Control of ground-state pluripotency by allelic regulation of Nanog." in: Nature, Vol. 483, Issue 7390, pp. 470-3, (2012) (PubMed).
: "MED12 alterations in both human benign and malignant uterine soft tissue tumors." in: PLoS ONE, Vol. 7, Issue 6, pp. e40015, (2012) (PubMed).
: "Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines." in: Experimental hematology, Vol. 40, Issue 10, pp. 800-10, (2012) (PubMed).
: "A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 25, Issue 2, pp. 348-59, (2011) (PubMed).
: "Core promoter recognition complex changes accompany liver development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 10, pp. 3906-11, (2011) (PubMed).
Aliases for MED12 抗体
mediator complex subunit 12 (MED12) 抗体mediator complex subunit 12 (Med12) 抗体
mediator complex subunit 12 (med12) 抗体
230kDa 抗体
ARC240 抗体
CAGH45 抗体
FGS1 抗体
HOPA 抗体
MED12S 抗体
Mopa 抗体
OHDOX 抗体
OKS 抗体
OPA-1 抗体
OPA1 抗体
TNRC11 抗体
Tnrc11 抗体
TRAP230 抗体
Trap230 抗体
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