MECP2 抗体
(Methyl CpG Binding Protein 2 (MECP2))
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009].
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Latest Publications for our MECP2 抗体
: "Linc-ROR promotes the progression of breast cancer and decreases the sensitivity to rapamycin through miR-194-3p targeting MECP2." in: Molecular oncology, Vol. 14, Issue 9, pp. 2231-2250, (2021) (PubMed).: "Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi ..." in: Epigenetics & chromatin, Vol. 13, Issue 1, pp. 13, (2020) (PubMed).
: "The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability." in: Cancer cell, Vol. 34, Issue 5, pp. 823-839.e7, (2019) (PubMed).
: "Expression of Phospho-MeCP2s in the Developing Rat Brain and Function of Postnatal MeCP2 in Cerebellar Neural Cell Development." in: Neuroscience bulletin, Vol. 33, Issue 1, pp. 1-16, (2017) (PubMed).
: "CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression." in: Nature communications, Vol. 8, Issue 1, pp. 355, (2017) (PubMed).
: "Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology." in: Frontiers in molecular neuroscience, Vol. 10, pp. 69, (2017) (PubMed).
: "MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome." in: Nature communications, Vol. 7, pp. 10552, (2016) (PubMed).
: "Geniposide alleviates inflammation by suppressing MeCP2 in mice with carbon tetrachloride-induced acute liver injury and LPS-treated THP-1 cells." in: International immunopharmacology, (2015) (PubMed).
: "Prenatal caloric restriction enhances DNA methylation and MeCP2 recruitment with reduced murine placental glucose transporter isoform 3 expression." in: The Journal of nutritional biochemistry, Vol. 25, Issue 2, pp. 259-66, (2014) (PubMed).
: "Modeling neurogenesis impairment in Down syndrome with induced pluripotent stem cells from Trisomy 21 amniotic fluid cells." in: Experimental cell research, Vol. 319, Issue 4, pp. 498-505, (2013) (PubMed).
Aliases for MECP2 抗体
methyl-CpG binding protein 2 (MECP2) 抗体methyl CpG binding protein 2 (Mecp2) 抗体
methyl CpG binding protein 2 (mecp2) 抗体
methyl-CpG binding protein 2 S homeolog (mecp2.S) 抗体
1500041B07Rik 抗体
AUTSX3 抗体
BB130002 抗体
D630021H01Rik 抗体
Mbd5 抗体
MRX16 抗体
MRX79 抗体
MRXS13 抗体
MRXSL 抗体
PPMX 抗体
RS 抗体
RTS 抗体
RTT 抗体
WBP10 抗体
wu:fk96a04 抗体
zgc:111857 抗体
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