MECP2 产品
(Methyl CpG Binding Protein 2 (MECP2))
Categories
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009].
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Featured MECP2 Categories
MECP2 抗体
High quality antibodies with extensive validation data.
MECP2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
MECP2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MECP2 抗体
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Reactivity
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Cat. No.
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Datasheet
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Human
Application
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- (8)
Cat. No.
ABIN5542475
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (5)
Cat. No.
ABIN517816
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IHC
Validations
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Cat. No.
ABIN5663752
Quantity
100 μL
Datasheet
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Recommended MECP2 ELISA试剂盒
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Analytical Method
Quantitative Sandwich ELISA
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Cat. No.
ABIN6962645
Quantity
96 tests
Datasheet
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Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
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- (1)
Cat. No.
ABIN6968595
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
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Cat. No.
ABIN6960688
Quantity
96 tests
Datasheet
Datasheet
Recommended MECP2 蛋白
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Source
Wheat germ
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- (1)
Cat. No.
ABIN1310622
Quantity
10 μg
Datasheet
Datasheet
Reactivity
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Source
Escherichia coli (E. coli)
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- (1)
Cat. No.
ABIN7123936
Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Cat. No.
ABIN1310624
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Latest Publications for our MECP2 Products
: "Linc-ROR promotes the progression of breast cancer and decreases the sensitivity to rapamycin through miR-194-3p targeting MECP2." in: Molecular oncology, Vol. 14, Issue 9, pp. 2231-2250, (2021) (PubMed).: "Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi ..." in: Epigenetics & chromatin, Vol. 13, Issue 1, pp. 13, (2020) (PubMed).
: "An electrochemiluminescence based assay for quantitative detection of endogenous and exogenously applied MeCP2 protein variants." in: Scientific reports, Vol. 9, Issue 1, pp. 7929, (2020) (PubMed).
: "The significance of the increased expression of phosphorylated MeCP2 in the membranes from patients with proliferative diabetic retinopathy." in: Scientific reports, Vol. 6, pp. 32850, (2018) (PubMed).
: "Expression of Phospho-MeCP2s in the Developing Rat Brain and Function of Postnatal MeCP2 in Cerebellar Neural Cell Development." in: Neuroscience bulletin, Vol. 33, Issue 1, pp. 1-16, (2017) (PubMed).
: "CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression." in: Nature communications, Vol. 8, Issue 1, pp. 355, (2017) (PubMed).
: "Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology." in: Frontiers in molecular neuroscience, Vol. 10, pp. 69, (2017) (PubMed).
: "Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior." in: Nature neuroscience, Vol. 19, Issue 11, pp. 1497-1505, (2016) (PubMed).
: "MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome." in: Nature communications, Vol. 7, pp. 10552, (2016) (PubMed).
: "Geniposide alleviates inflammation by suppressing MeCP2 in mice with carbon tetrachloride-induced acute liver injury and LPS-treated THP-1 cells." in: International immunopharmacology, (2015) (PubMed).
Synonyms and alternative names related to MECP2
methyl-CpG binding protein 2 (MECP2), methyl CpG binding protein 2 (Mecp2), methyl CpG binding protein 2 (mecp2), methyl-CpG binding protein 2 S homeolog (mecp2.S), 1500041B07Rik, AUTSX3, BB130002, D630021H01Rik, Mbd5, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, WBP10, wu:fk96a04, zgc:111857Protein level used designations for MECP2
- meCp-2 protein
- methyl-CpG-binding protein 2
- meCP-2 protein
- methyl-CpG-binding protein MeCP2
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