MDM2 抗体
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| MDM2 抗体 (AA 100-200) (Atto 594) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| MDM2 抗体 (AA 100-200) (Biotin) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| MDM2 抗体 (AA 100-200) (PerCP) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| MDM2 抗体 (AA 100-200) (FITC) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| MDM2 抗体 (AA 100-200) (HRP) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| MDM2 抗体 (AA 100-200) (PE) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| MDM2 抗体 | 人, 小鼠, 猴 | 兔 Polyclonal |
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| MDM2 抗体 (pSer395) | 人 | 兔 Polyclonal |
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| MDM2 抗体 (AA 101-201) | 人 | 小鼠 Monoclonal |
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| MDM2 抗体 (Internal Region) | 人, 小鼠, 大鼠, 猴 | 兔 Polyclonal |
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| MDM2 抗体 (AA 374-391) | 人 | 兔 Polyclonal |
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| MDM2 抗体 | 人 | 小鼠 Monoclonal |
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| MDM2 抗体 (Ser880) | 人, 小鼠, 猴 | 兔 Polyclonal |
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| MDM2 抗体 (AA 1-321) | 人 | 兔 Polyclonal |
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| MDM2 抗体 (AA 1-491) | 人 | 兔 Polyclonal |
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| MDM2 抗体 (Internal Region) | 人 | 山羊 Polyclonal |
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| MDM2 抗体 (pSer166) | 人 | 兔 Polyclonal |
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| MDM2 抗体 (AA 196-435) | 人 | 小鼠 Monoclonal |
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| MDM2 抗体 (pSer395) | 人 | 兔 Polyclonal |
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| MDM2 抗体 (pThr218) | 人 | 兔 Polyclonal |
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Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Atto 594
- 抗原表位
- AA 100-200
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Biotin
- 抗原表位
- AA 100-200
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- PerCP
- 抗原表位
- AA 100-200
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- FITC
- 抗原表位
- AA 100-200
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- HRP
- 抗原表位
- AA 100-200
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- PE
- 抗原表位
- AA 100-200
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- IHC (fp) (Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections): 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- DB (Dot Blot: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- pSer395
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- IHC (fp) (Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections): 有验证图片)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 1A7
- 标记
- unconjugated
- 抗体亚型
- IgG1 kappa
- 抗原表位
- AA 101-201
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- IHC (Immunohistochemistry: 所列应用)
- IF (Immunofluorescence: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠, 猴
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- Internal Region
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 374-391
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 所列应用)
- ELISA (ELISA: 所列应用)
- IF (Immunofluorescence: 所列应用)
- 适用
- 人, 小鼠, 猴
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- Ser880
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 1-321
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1-491
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 质量等级
- Verified
- 适用
- 人
- 宿主
- 山羊
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- Internal Region
Primary Antibody
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- WB (Western Blotting: 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- FACS (Flow Cytometry: 所列应用)
- IHC (fro) (Immunohistochemistry (Frozen Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pSer166
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 1806CT309-52-1
- 标记
- unconjugated
- 抗体亚型
- IgG1 kappa
- 抗原表位
- AA 196-435
Primary Antibody
- DB (Dot Blot: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB07988
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- pSer395
Primary Antibody
- DB (Dot Blot: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB7869
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- pThr218
Latest Publications for our MDM2 抗体
: "The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and ..." in: The Journal of biological chemistry, Vol. 291, Issue 31, pp. 16339-47, (2017) (PubMed).
: "Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression." in: Molecular medicine reports, Vol. 15, Issue 4, pp. 1455-1460, (2017) (PubMed).
: "Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy." in: Investigative ophthalmology & visual science, Vol. 58, Issue 12, pp. 5361-5367, (2017) (PubMed).
: "P53-Derived peptides conjugation to PEI: an approach to producing versatile and highly efficient targeted gene delivery carriers into cancer cells." in: Expert opinion on drug delivery, Vol. 13, Issue 4, pp. 477-91, (2016) (PubMed).
: "RASSF10 suppresses colorectal cancer growth by activating P53 signaling and sensitizes colorectal cancer cell to docetaxel." in: Oncotarget, Vol. 6, Issue 6, pp. 4202-13, (2015) (PubMed).
: "Fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro." in: International journal of oncology, Vol. 46, Issue 4, pp. 1677-84, (2015) (PubMed).
: "The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer." in: The Journal of biological chemistry, Vol. 290, Issue 37, pp. 22649-61, (2015) (PubMed).
: "CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer." in: Oncology reports, Vol. 32, Issue 6, pp. 2703-9, (2014) (PubMed).
: "USP7/HAUSP stimulates repair of oxidative DNA lesions." in: Nucleic acids research, Vol. 39, Issue 7, pp. 2604-9, (2011) (PubMed).
: "Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53." in: Molecular and cellular biology, Vol. 31, Issue 9, pp. 1788-99, (2011) (PubMed).
: "Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression." in: Molecular medicine reports, Vol. 15, Issue 4, pp. 1455-1460, (2017) (PubMed).
: "Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy." in: Investigative ophthalmology & visual science, Vol. 58, Issue 12, pp. 5361-5367, (2017) (PubMed).
: "P53-Derived peptides conjugation to PEI: an approach to producing versatile and highly efficient targeted gene delivery carriers into cancer cells." in: Expert opinion on drug delivery, Vol. 13, Issue 4, pp. 477-91, (2016) (PubMed).
: "RASSF10 suppresses colorectal cancer growth by activating P53 signaling and sensitizes colorectal cancer cell to docetaxel." in: Oncotarget, Vol. 6, Issue 6, pp. 4202-13, (2015) (PubMed).
: "Fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro." in: International journal of oncology, Vol. 46, Issue 4, pp. 1677-84, (2015) (PubMed).
: "The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer." in: The Journal of biological chemistry, Vol. 290, Issue 37, pp. 22649-61, (2015) (PubMed).
: "CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer." in: Oncology reports, Vol. 32, Issue 6, pp. 2703-9, (2014) (PubMed).
: "USP7/HAUSP stimulates repair of oxidative DNA lesions." in: Nucleic acids research, Vol. 39, Issue 7, pp. 2604-9, (2011) (PubMed).
: "Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53." in: Molecular and cellular biology, Vol. 31, Issue 9, pp. 1788-99, (2011) (PubMed).
Aliases for MDM2 抗体
MDM2 proto-oncogene (MDM2) 抗体MDM2 proto-oncogene S homeolog (mdm2.S) 抗体
MDM2 proto-oncogene (Mdm2) 抗体
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2) 抗体
MDM2 oncogene, E3 ubiquitin protein ligase (mdm2) 抗体
transformed mouse 3T3 cell double minute 2 (Mdm2) 抗体
1700007J15Rik 抗体
AA415488 抗体
ACTFS 抗体
hdm2 抗体
HDMX 抗体
Mdm-2 抗体
zgc:109834 抗体
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