MDC1 抗体
(Mdc1 (MDC1))
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008].
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Latest Publications for our MDC1 抗体
: "JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity." in: Cell death and differentiation, (2019) (PubMed).: "Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks." in: Nucleic acids research, Vol. 47, Issue 7, pp. 3467-3484, (2019) (PubMed).
: "SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression." in: Scientific reports, Vol. 7, Issue 1, pp. 3842, (2017) (PubMed).
: "RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment." in: The Journal of biological chemistry, Vol. 291, Issue 18, pp. 9396-410, (2016) (PubMed).
: "Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network." in: Chromosoma, (2016) (PubMed).
: "Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites." in: Nucleic acids research, Vol. 44, Issue 3, pp. e27, (2016) (PubMed).
: "The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex." in: PLoS ONE, Vol. 10, Issue 12, pp. e0144957, (2015) (PubMed).
: "The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence." in: Molecular and cellular biology, Vol. 34, Issue 10, pp. 1733-46, (2014) (PubMed).
: "DNA damage to a single chromosome end delays anaphase onset." in: The Journal of biological chemistry, Vol. 289, Issue 33, pp. 22771-84, (2014) (PubMed).
: "Listeria monocytogenes dampens the DNA damage response." in: PLoS pathogens, Vol. 10, Issue 10, pp. e1004470, (2014) (PubMed).
Aliases for MDC1 抗体
mediator of DNA damage checkpoint 1 (Mdc1) 抗体mediator of DNA damage checkpoint 1 (MDC1) 抗体
mediator of DNA-damage checkpoint 1 (MDC1) 抗体
6820401C03 抗体
AA413496 抗体
mKIAA0170 抗体
Nfbd1 抗体
NFBD1 抗体
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