MCAM 蛋白
(Melanoma Cell Adhesion Molecule (MCAM))
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
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22 results
MALS verified
MCAM
宿主: Cynomolgus
宿主: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Latest Publications for our MCAM 蛋白
: "The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis." in: Nature communications, Vol. 8, pp. 15279, (2018) (PubMed).: "Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis." in: Cell research, Vol. 27, Issue 3, pp. 352-372, (2017) (PubMed).
: "CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development." in: Cell research, Vol. 25, Issue 3, pp. 275-87, (2015) (PubMed).
: "Selection of scFv Antibody Fragments Binding to Human Blood versus Lymphatic Endothelial Surface Antigens by Direct Cell Phage Display." in: PLoS ONE, Vol. 10, Issue 5, pp. e0127169, (2015) (PubMed).
: "Monoclonal antibodies to human laminin ?4 chain globular domain inhibit tumor cell adhesion and migration on laminins 411 and 421, and binding of ?6?1 integrin and MCAM to ?4-laminins." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 36, pp. 5-14, (2014) (PubMed).
: "Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension." in: Nature communications, Vol. 4, pp. 2803, (2013) (PubMed).
: "Up-regulation of MUC18 in airway epithelial cells by IL-13: implications in bacterial adherence." in: American journal of respiratory cell and molecular biology, Vol. 44, Issue 5, pp. 606-13, (2011) (PubMed).
Aliases for MCAM 蛋白
melanoma cell adhesion molecule (MCAM) 蛋白melanoma cell adhesion molecule (Mcam) 蛋白
melanoma cell adhesion molecule b (mcamb) 蛋白
1-gicerin 蛋白
AV025631 蛋白
CD146 蛋白
cd146 蛋白
CD149 蛋白
gicerin 蛋白
id:ibd3512 蛋白
mcam 蛋白
MCAM 蛋白
MUC18 蛋白
Muc18 蛋白
s-endo 蛋白
s-gicerin 蛋白
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