Use your antibodies-online credentials, if available.
抗Human PAK2 抗体:
抗Mouse (Murine) PAK2 抗体:
抗Rat (Rattus) PAK2 抗体:
Human Monoclonal PAK2 Primary Antibody for ICC, IHC - ABIN969338
Chu, Wu, Liao, Pardo, Zhao, Li, Mendenhall, Pali, Shen, Yu, Taylor, Aversa, Molineaux, Payan, Masuda: A novel role for p21-activated protein kinase 2 in T cell activation. in Journal of immunology (Baltimore, Md. : 1950) 2004
Show all 2 Pubmed References
Human Polyclonal PAK2 Primary Antibody for IHC (p), WB - ABIN2476049
Rudel, Bokoch: Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. in Science (New York, N.Y.) 1997
Show all 3 Pubmed References
Human Polyclonal PAK2 Primary Antibody for IHC, ELISA - ABIN1002956
Jaffer, Chernoff: p21-activated kinases: three more join the Pak. in The international journal of biochemistry & cell biology 2002
Show all 3 Pubmed References
Human Polyclonal PAK2 Primary Antibody for IHC, ELISA - ABIN1002955
Vilas, Corvi, Plummer, Seime, Lambkin, Berthiaume: Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 3 Pubmed References
Human Polyclonal PAK2 Primary Antibody for IP, WB - ABIN253074
Qu, Misaghi, Izrael-Tomasevic, Newton, Gilmour, Lamkanfi, Louie, Kayagaki, Liu, Kömüves, Cupp, Arnott, Monack, Dixit: Phosphorylation of NLRC4 is critical for inflammasome activation. in Nature 2012
EphrinB ligands B2a and B3b, the Ephb4a (显示 EPHB4 抗体) receptor and the Pak2a kinase are required for the development of pharyngeal pouches and the segmentation of the posterior facial skeleton.
Essential in vivo role for betaPix (显示 ARHGEF7 抗体) and Pak2a during embryonic development and a previously unrecognized pathway specifically involved in cerebrovascular stabilization. [BetaPix (显示 ARHGEF7 抗体) AND Pak2a]
Data provide evidence for a critical function of Pak2 in vascular integrity and demonstrate a severe disease phenotype resulting from loss of Pak2 function.
leukaemic cells explicitly require PAK2 to grow towards an extracellular matrix. PAK2-deficient cells fail to form colonies in methylcellulose and to induce lymphomas in vivo. PAK2 might therefore be the critical isoform in leukaemic cells by controlling tumour growth
Results show that PAK2 kinase plays an alternative anti-apoptotic role, phosphorylating caspase-7 (显示 CASP7 抗体) and promoting unfettered cell growth and chemotherapeutic resistance.
We found that overexpression of miR (显示 MLXIP 抗体)-137 inhibited the proliferation of melanoma cells, which could be phenocopied by knockdown of PAK2 using siRNAs.
PAK2 is a direct effector of TSC1 (显示 TSC1 抗体)-TSC2 (显示 TSC2 抗体)-RHEB (显示 RHEB 抗体) signaling and a new target for rational drug therapy in TSC (显示 SLC12A3 抗体).
Nef exploits PAK2 in a stepwise mechanism in which its kinase activity cooperates with an adaptor function for the exocyst complex to inhibit host cell actin dynamics.
Cytoplasmic Pak2 may promote cell proliferation in normal endometrium during menstrual cycle.
Further analyses show that HDAC6 (显示 HDAC6 抗体) may promote growth of GBM cells through inhibition of SMAD2 (显示 SMAD2 抗体) phosphorylation to downregulate p21 (显示 CDKN1A 抗体)
Pak1 (显示 PAK1 抗体) and Pak2 counteract centrosome separation in a kinase-dependent manner.
Findings indicate that repression of microRNA miR (显示 MLXIP 抗体)-134 and consequent up-regulation of p21-activated kinase 2 (Pak2) might contribute to paclitaxel resistance.
Inhibition of PAK activation at late G2-phase centrosomes caused by Rac1 inactivation coincides with impeded activation of Aurora A (显示 AURKA 抗体) and the CyclinB (显示 CCNB1 抗体)/Cdk1 (显示 CDK1 抗体) complex and delayed mitotic entry.
PAK2 acts as a Rac1-dependent negative regulator of neuronal glucose uptake and insulin (显示 INS 抗体) sensitivity.
These results identify Pak1 (显示 PAK1 抗体) and Pak2 as redundant regulators of myoblast differentiation in vitro and in vivo and as components of the promyogenic Ncad (显示 CDH2 抗体)/Cdo (显示 CDO1 抗体)/Cdc42 (显示 CDC42 抗体) signaling pathway.
PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.
Data indicate that resveratrol treatment inhibits neuronal glucose uptake via P21-activated kinase 2 (PAK2).
Mechanistic insights into the role of Pak2 in hematopoietic stem cells migration and homing.
Pak2 disruption decreased the survival and proliferation of multicytokine stimulated immature progenitors.
The data suggest that Pak2 controls thymic Natural Killer T-cell development by providing a signal that links Egr2 (显示 EGR2 抗体) to induce PLZF (显示 ZBTB16 抗体), in part by regulating signaling lymphocyte activation molecule (显示 SLAMF1 抗体) 6 expression.
In adult endothelial cells, Pak2 depletion leads to severe apoptosis and acute angiogenesis defects, and in adult mice, endothelial Pak2 deletion leads to increased vascular permeability.
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance
Failure to induce proper actin cytoskeletal remodeling impaired PLCgamma1 and Erk1/2 signaling in the absence of Pak2, uncovering the critical function of Pak2 as an essential regulator that governs the actin cytoskeleton-dependent signaling
Basement membrane proteins promote PAK2 Ser (显示 SIGLEC1 抗体)-20 phosphorylation through enhanced eNOS (显示 NOS3 抗体) activation and NO production.
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
p21 (CDKN1A)-activated kinase 2
, p21-activated kinase 2
, serine/threonine-protein kinase PAK 2
, p21 activated kinase 2
, S6/H4 kinase
, p21-activated kinase I
, p21-activated protein kinase I